Multagenicity of five food additives in Ames/Salmonella/microsome test

被引:13
作者
Kayraldiz, Ahmet
Kaya, Fatma Funda
Canimoglu, Semir
Rencuzogullari, Eyyup [1 ]
机构
[1] Cukurova Univ, Inst Nat & Appl Sci, Dept Biol, Adana, Turkey
[2] Cukurova Univ, Fac Arts & Sci, Dept Biol, Adana, Turkey
关键词
ames test; food additives; nitrate; nitrite; sulphate; sulphite;
D O I
10.1007/BF03174993
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The mutagenic activity of five food additives (K2S2O5 : potassium metabisulphite, KMB; K2SO4: potassium sulphate, KS; Na2SO3: sodium sulphite, SS; KNO3: potassium nitrate, KN; NaNO3: sodium nitrate, SN) were investigated using histidin auxotrophs TA98 and TA100 strains of Salmonella typhimurium in the presence or absence of S9 mix. The test substances were investigated for their mutagenic effects at non toxic concentrations of 0.83, 1.66, 3.33 and 5.00 mg/plate with and without S9 mix. All the test substances were not mutagenic on TA98 and TA100 strains of Salmonella typhimurium in the presence or absence of S9 mix except KS and SN. KS and SN showed a weak mutagenic effect on TA100 strain in the absence of S9 mix.
引用
收藏
页码:129 / 133
页数:5
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