Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum

被引：25
作者：
Prieto, JM
Giner, RM
Recio, MC
Schinella, G
Máñez, S
Ríos, JL
机构：
[1] Univ Valencia, Dept Farmacol, E-46100 Burjassot, Spain
[2] Univ Nacl La Plata, Fac Ciencias Med, Catedra Farmacol, La Plata, Argentina
来源：
PLANTA MEDICA | 2002年 / 68卷 / 04期
关键词：
D O I：
10.1055/s-2002-26747
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The topical anti-inflammatory activity of Haplophyllum hispanicum Spach is due to the presence of arylnaphthalene-type lignans acting as 5-lipoxygenase (5-LOX) inhibitors. The effects of the methanolic extract of this species on cellular systems have been determined by HPLC-DAD analysis. Diphyllin acetylapioside proved to be the main lignan endowed with 5-LOX inhibitory activity.
引用
收藏
页码：359 / 360
页数：2
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