Diphyllin acetylapioside, a 5-lipoxygenase inhibitor from Haplophyllum hispanicum

被引：25

作者：

Prieto, JM

Giner, RM

Recio, MC

Schinella, G

Máñez, S

Ríos, JL

机构：

[1] Univ Valencia, Dept Farmacol, E-46100 Burjassot, Spain

[2] Univ Nacl La Plata, Fac Ciencias Med, Catedra Farmacol, La Plata, Argentina

来源：

PLANTA MEDICA | 2002年 / 68卷 / 04期

关键词：

D O I：

10.1055/s-2002-26747

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The topical anti-inflammatory activity of Haplophyllum hispanicum Spach is due to the presence of arylnaphthalene-type lignans acting as 5-lipoxygenase (5-LOX) inhibitors. The effects of the methanolic extract of this species on cellular systems have been determined by HPLC-DAD analysis. Diphyllin acetylapioside proved to be the main lignan endowed with 5-LOX inhibitory activity.

引用

页码：359 / 360

页数：2

共 14 条

[1]

BERGMEYER H.U., 1974, METHODS ENZYMATIC AN, P574, DOI DOI 10.1016/B978-0-12-091302-2.50010-4

[2] THE ROLE OF LEUKOTRIENES IN INFLAMMATION [J].