A Case of Toxic Epidermal Necrolysis Induced by Allopurinol with Human Herpesvirus-6 Reactivation

被引：5

作者：

Watanabe, Yuko ^{[1
]}

Matsukura, Setsuko ^{[2
]}

Isoda, Yuji ^{[2
]}

Morita, Akiko ^{[2
]}

Aihara, Michiko ^{[1
]}

Kambara, Takeshi ^{[2
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Environm Immunodermatol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Med Ctr, Dept Dermatol, Yokohama, Kanagawa 2360004, Japan

来源：

ACTA DERMATO-VENEREOLOGICA | 2013年 / 93卷 / 06期

关键词：

INDUCED HYPERSENSITIVITY SYNDROME; DRESS-SYNDROME; 6; INFECTION; HUMAN-HERPESVIRUS-6; ASSOCIATION;

D O I：

10.2340/00015555-1610

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) or drug rash with eosinophilia and systemic symptoms (DRESS) (1, 2) are severe adverse drug reactions (ADRs). Recently, human herpesvirus 6 (HHV-6) reactivation has been observed frequently in patients with DIHS/DRESS, but not in SJS/TEN (3-5). Therefore, it has been suggested that HHV-6 is closely related to the pathogenesis of DIHS, but not to that of SJS/TEN (6, 7). We report here a case of TEN induced by allopurinol, accompanied by HHV-6 reactivation. © 2013 Acta Dermato-Venereologica.

引用

页码：731 / 732

页数：2

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