A Case of Toxic Epidermal Necrolysis Induced by Allopurinol with Human Herpesvirus-6 Reactivation

被引：4

作者：

Watanabe, Yuko ^{[1
]}

Matsukura, Setsuko ^{[2
]}

Isoda, Yuji ^{[2
]}

Morita, Akiko ^{[2
]}

Aihara, Michiko ^{[1
]}

Kambara, Takeshi ^{[2
]}

机构：

[1] Yokohama City Univ, Grad Sch Med, Dept Environm Immunodermatol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

[2] Yokohama City Univ, Med Ctr, Dept Dermatol, Yokohama, Kanagawa 2360004, Japan

来源：

ACTA DERMATO-VENEREOLOGICA | 2013年 / 93卷 / 06期

关键词：

INDUCED HYPERSENSITIVITY SYNDROME; DRESS-SYNDROME; 6; INFECTION; HUMAN-HERPESVIRUS-6; ASSOCIATION;

D O I：

10.2340/00015555-1610

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) or drug rash with eosinophilia and systemic symptoms (DRESS) (1, 2) are severe adverse drug reactions (ADRs). Recently, human herpesvirus 6 (HHV-6) reactivation has been observed frequently in patients with DIHS/DRESS, but not in SJS/TEN (3-5). Therefore, it has been suggested that HHV-6 is closely related to the pathogenesis of DIHS, but not to that of SJS/TEN (6, 7). We report here a case of TEN induced by allopurinol, accompanied by HHV-6 reactivation. © 2013 Acta Dermato-Venereologica.

引用

页码：731 / 732

页数：2

共 10 条

[1] The DRESS Syndrome: A Literature Review
Cacoub, Patrice
Musette, Philippe
Descamps, Vincent
Meyer, Olivier
Speirs, Chris
Finzi, Laetitia
Roujeau, Jean Claude
[J]. AMERICAN JOURNAL OF MEDICINE, 2011, 124 (07) : 588 - 597
[2] Descamps V, 2001, ARCH DERMATOL, V137, P301
[3] Toxic Epidermal Necrolysis with Prominent Facial Pustules: A Case with Reactivation of Human Herpesvirus 7
Honma, Masaru
Tobisawa, Shinichi
Iinuma, Shin
Shibuya, Takashi
Komatsu, Shigetsuna
Takahashi, Ichiro
Ishida-Yamamoto, Akemi
Iizuka, Hajime
[J]. DERMATOLOGY, 2010, 221 (04) : 306 - 308
[4] High-Level Human Herpesvirus-6 Viremia Associated With Onset of Stevens-Johnson Syndrome: Report of Two Cases
Peppercorn, Amanda F.
Miller, Melissa B.
Fitzgerald, David
Weber, David J.
Groben, Pamela A.
Cairns, Bruce A.
[J]. JOURNAL OF BURN CARE & RESEARCH, 2010, 31 (02) : 365 - 368
[5] SEVERE ADVERSE CUTANEOUS REACTIONS TO DRUGS
ROUJEAU, JC
STERN, RS
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (19) : 1272 - 1285
[6] The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations
Shiohara, T.
Iijima, M.
Ikezawa, Z.
Hashimoto, K.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2007, 156 (05) : 1083 - 1084
[7] Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome
Suzuki, Y
Inagi, R
Aono, T
Yamanishi, K
Shiohara, T
[J]. ARCHIVES OF DERMATOLOGY, 1998, 134 (09) : 1108 - 1112
[8] Toxic epidermal necrolysis due to zonisamide associated with reactivation of human herpesvirus 6
Teraki, Yuichi
Murota, Haruhiko
Izaki, Seiichi
[J]. ARCHIVES OF DERMATOLOGY, 2008, 144 (02) : 232 - 235
[9] Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome
Tohyama, M.
Hashimoto, K.
Yasukawa, M.
Kimura, H.
Horikawa, T.
Nakajima, K.
Urano, Y.
Matsumoto, K.
Iijima, M.
Shear, N. H.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2007, 157 (05) : 934 - 940
[10] Severe hypersensitivity syndrome due to sulfasalazine associated with reactivation of human herpesvirus 6
Tohyama, M
Yahata, Y
Yasukawa, M
Inagi, R
Urano, Y
Yamanishi, K
Hashimoto, K
[J]. ARCHIVES OF DERMATOLOGY, 1998, 134 (09) : 1113 - 1117

← 1 →