Severe paradoxical disease activation following alemtuzumab treatment for multiple sclerosis

被引:5
作者
Brannigan, Jamie [1 ]
Jones, Joanne L. [2 ]
Stacpoole, Sybil R. L. [1 ,2 ,3 ]
机构
[1] Univ Cambridge, Jesus Coll, Cambridge CB2 1TN, England
[2] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Dept Neurol, Cambridge, England
[3] North West Anglia NHS Fdn Trust, Peterborough City Hosp, Dept Neurol, Peterborough, Cambs, England
来源
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION | 2020年 / 7卷 / 05期
基金
英国惠康基金;
关键词
D O I
10.1212/NXI.0000000000000799
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
A 39-year-old right-handed agricultural service engineer developed rapidly evolving severe relapsing-remitting multiple sclerosis (MS). MRI showed multiple T2 hyperintensities throughout his neuroaxis (figure, A). Several lesions showed restricted diffusion, and 2 enhanced. He received steroids for each relapse, making a full recovery (Expanded Disability Status Score [EDSS] 0).
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页数:3
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  • [1] Severe B-cell-mediated CNS disease secondary to alemtuzumab therapy
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    Dendrou, Calliope A.
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    Grueter, Thomas
    Postert, Thomas
    Matzke, Mike
    Stephanik, Heike
    Fugger, Lars
    Gold, Ralf
    [J]. LANCET NEUROLOGY, 2017, 16 (02) : 104 - 106
  • [2] Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation
    Jones, Joanne L.
    Thompson, Sara A. J.
    Loh, Priscilla
    Davies, Jessica L.
    Tuohy, Orla C.
    Curry, Allison J.
    Azzopardi, Laura
    Hill-Cawthorne, Grant
    Fahey, Michael T.
    Compston, Alastair
    Coles, Alasdair J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (50) : 20200 - 20205
  • [3] Activation of disease during therapy with alemtuzumab in 3 patients with multiple sclerosis
    Wehrum, Thomas
    Beume, Lena-Alexandra
    Stich, Oliver
    Mader, Irina
    Maeurer, Mathias
    Czaplinski, Adam
    Weiller, Cornelius
    Rauer, Sebastian
    [J]. NEUROLOGY, 2018, 90 (07) : E601 - E605
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    Pearson, Owen
    Illes, Zsolt
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    Petheram, Kate
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    Killestein, Joep
    Malmestrom, Clas
    Tallantyre, Emma
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    [J]. NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2017, 4 (02):