Engineering of perfluorooctylbromide polypyrrole nano-/microcapsules for simultaneous contrast enhanced ultrasound imaging and photothermal treatment of cancer

被引：57

作者：

Zha, Zhengbao ^{[3
]}

Wang, Jinrui ^{[1
,2
]}

Zhang, Shuhai ^{[3
]}

Wang, Shumin ^{[1
,2
]}

Qu, Enze ^{[1
,2
]}

Zhang, Youyi ^{[1
,2
]}

Dai, Zhifei ^{[1
,2
]}

机构：

[1] Peking Univ, Coll Engn, Beijing 100871, Peoples R China

[2] Peking Univ, Hosp 3, Beijing 100871, Peoples R China

[3] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China

来源：

BIOMATERIALS | 2014年 / 35卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Oil-in-water emulsion; Polypyrrole capsules; Perfluorooctylbromide; Ultrasound imaging; Photothermal therapy; COPPER SULFIDE NANOPARTICLES; GOLD NANOCAGES; THERAPY; ABLATION; CELLS; AGENT; DESTRUCTION; MICELLES; DELIVERY; UNIFORM;

D O I：

10.1016/j.biomaterials.2013.09.084

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A versatile oil-in-water emulsion method has been explored for constructing water-dispersible polypyrrole (PPy) nano-/microcapsules with a soluble PPy complex as multifunctional photothermal agents for tumor ablation. In this work, both PPy nanocapsules (280.4 +/- 79.0 nm) and microcapsules (1.31 +/- 0.45 mu m) with liquid perfluorooctylbromide (PFOB) core could be obtained by simply tuning the process energy for emulsion formation from ultrasonication to homogenization. Owing to the encapsulated liquid PFOB and strong near-infrared (NIR) absorption of PPy shell, the resulted PPy capsules showed great promise in ultrasound imaging guided photothermal ablation of tumor cells without inducing any significant side effect. Thus, it is anticipated that fine-tuning of the other encapsulated drugs or functional materials in PPy capsules would foster avenues for the development of multifunctional platforms for cancer treatments. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：287 / 293

页数：7

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