Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome

被引：7
|
作者：
Laurent, Julien
Paly, Evelyne
Marche, Patrice N.
London, Jacqueline
机构：
[1] CEA, DRDD, ICH, INSERM U548,Lab Immunochim, F-38054 Grenoble 09, France
[2] Univ Paris 07, EA 3508, F-75251 Paris 05, France
[3] CePo Ctr Pluridsciplinaire Oncol, Lausanne, Switzerland
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2006年 / 40卷 / 11期
关键词：
Cu/Zn superoxide dismutase; Down syndrome; lymph nodes; reactive oxygen species; spleen; thymus; transgenic; T lymphocytes; free radicals;
D O I：
10.1016/j.freeradbiomed.2006.01.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model of Down syndrome, exhibit premature thymic involution. We have performed a flow cytometry analysis of the developing thymus in these homozygous transgenic mice (hSOD1/hSOD1: Tg-SOD). Longitudinal follow-up analysis from day 3 to day 280 showed an early thymic development in Tg-SOD mice compared with controls. This early thymic development was associated with an increased migration of mature T cells to peripheral lymphoid organs. BrdU labeling showed no difference between Tg-SOD and control mice, confirming that the greater number of peripheral T cells in Tg-SOD mice was not due to extensive proliferation of these cells but rather to a greater pool of emigrant T cells in Tg-SOD. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1971 / 1980
页数：10
相关论文
共 50 条
  • [41] Transgenic mice overexpressing the human DSCR1 gene: a model to study Down syndrome-like abnormalities.
    Fillat, C
    Dierssen, M
    Oset, M
    Martinez-Cue, C
    Vallina, IF
    Baamonde, C
    Nadal, M
    Pritchard, M
    Fuentes, JJ
    Florez, J
    Estivill, X
    AMERICAN JOURNAL OF HUMAN GENETICS, 1997, 61 (04) : A170 - A170
  • [42] Defective thymic progenitor development and mature T-cell responses in a mouse model for Down syndrome
    Lorenzo, Laureanne P. E.
    Shatynski, Kristen E.
    Clark, Sarah
    Yarowsky, Paul J.
    Williams, Mark S.
    IMMUNOLOGY, 2013, 139 (04) : 447 - 458
  • [43] Mitochondrial defects in transgenic mice expressing Cu,Zn Superoxide Dismutase mutations, the role of Copper Chaperone for SOD1
    Son, Marjatta
    Elliott, Jeffrey L.
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2014, 336 (1-2) : 1 - 7
  • [44] The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease
    Mourelatos, Z
    Gonatas, NK
    Stieber, A
    Gurney, ME
    DalCanto, MC
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) : 5472 - 5477
  • [45] Overexpression of Cu/Zn-superoxide dismutase and/or catalase in mice inhibits aorta smooth muscle cell proliferation
    Shi, MJ
    Yang, H
    Motley, ED
    Guo, ZM
    AMERICAN JOURNAL OF HYPERTENSION, 2004, 17 (05) : 450 - 456
  • [46] Early Hypoexcitability in a Subgroup of Spinal Motoneurons in Superoxide Dismutase 1 Transgenic Mice, a Model of Amyotrophic Lateral Sclerosis
    Filipchuk, Anton
    Pambo-Pambo, Arnaud
    Gaudel, Fanny
    Liabeuf, Sylvie
    Brocard, Cecile
    Gueritaud, Jean Patrick
    Durand, Jacques
    NEUROSCIENCE, 2021, 463 : 337 - 353
  • [47] IMPAIRED NEUROTRANSMITTER UPTAKE IN PC12 CELLS OVEREXPRESSING HUMAN CU/ZN-SUPEROXIDE DIMUTASE - IMPLICATION FOR GENE DOSAGE EFFECTS IN DOWN SYNDROME
    ELROYSTEIN, O
    GRONER, Y
    CELL, 1988, 52 (02) : 259 - 267
  • [48] Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase
    PeledKamar, M
    Lotem, J
    Wirguin, I
    Weiner, L
    Hermalin, A
    Groner, Y
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) : 3883 - 3887
  • [49] The protective role of copper/zinc superoxide dismutase (Cu/Zn-SOD) against myocardial ischemia reperfusion injury in transgenic mice
    Yoshida, T
    Ho, YS
    Engelman, RM
    Rousou, JA
    Flack, JE
    Deaton, D
    Das, DK
    CIRCULATION, 1997, 96 (08) : 3375 - 3375
  • [50] Neuronal death delay in hippocampal neurons from transgenic mice overexpressing the human copper/zinc superoxide dismutase gene (SOD1)
    Paris, D
    Toyama, K
    Dothi, A
    Thérond, P
    Sinet, PM
    Rouget, P
    London, J
    CYTOGENETICS AND CELL GENETICS, 1997, 79 (1-2): : 49 - 49
12345