Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome

被引：8
作者：
Laurent, Julien
Paly, Evelyne
Marche, Patrice N.
London, Jacqueline
机构：
[1] CEA, DRDD, ICH, INSERM U548,Lab Immunochim, F-38054 Grenoble 09, France
[2] Univ Paris 07, EA 3508, F-75251 Paris 05, France
[3] CePo Ctr Pluridsciplinaire Oncol, Lausanne, Switzerland
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2006年 / 40卷 / 11期
关键词：
Cu/Zn superoxide dismutase; Down syndrome; lymph nodes; reactive oxygen species; spleen; thymus; transgenic; T lymphocytes; free radicals;
D O I：
10.1016/j.freeradbiomed.2006.01.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model of Down syndrome, exhibit premature thymic involution. We have performed a flow cytometry analysis of the developing thymus in these homozygous transgenic mice (hSOD1/hSOD1: Tg-SOD). Longitudinal follow-up analysis from day 3 to day 280 showed an early thymic development in Tg-SOD mice compared with controls. This early thymic development was associated with an increased migration of mature T cells to peripheral lymphoid organs. BrdU labeling showed no difference between Tg-SOD and control mice, confirming that the greater number of peripheral T cells in Tg-SOD mice was not due to extensive proliferation of these cells but rather to a greater pool of emigrant T cells in Tg-SOD. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1971 / 1980
页数：10
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