Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome

被引：8

作者：

Laurent, Julien

Paly, Evelyne

Marche, Patrice N.

London, Jacqueline

机构：

[1] CEA, DRDD, ICH, INSERM U548,Lab Immunochim, F-38054 Grenoble 09, France

[2] Univ Paris 07, EA 3508, F-75251 Paris 05, France

[3] CePo Ctr Pluridsciplinaire Oncol, Lausanne, Switzerland

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2006年 / 40卷 / 11期

关键词：

Cu/Zn superoxide dismutase; Down syndrome; lymph nodes; reactive oxygen species; spleen; thymus; transgenic; T lymphocytes; free radicals;

D O I：

10.1016/j.freeradbiomed.2006.01.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model of Down syndrome, exhibit premature thymic involution. We have performed a flow cytometry analysis of the developing thymus in these homozygous transgenic mice (hSOD1/hSOD1: Tg-SOD). Longitudinal follow-up analysis from day 3 to day 280 showed an early thymic development in Tg-SOD mice compared with controls. This early thymic development was associated with an increased migration of mature T cells to peripheral lymphoid organs. BrdU labeling showed no difference between Tg-SOD and control mice, confirming that the greater number of peripheral T cells in Tg-SOD mice was not due to extensive proliferation of these cells but rather to a greater pool of emigrant T cells in Tg-SOD. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1971 / 1980

页数：10

共 62 条

[1] Early block in maturation is associated with thymic involution in mammary tumor-bearing mice [J].