Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome

被引：7
作者：
Laurent, Julien
Paly, Evelyne
Marche, Patrice N.
London, Jacqueline
机构：
[1] CEA, DRDD, ICH, INSERM U548,Lab Immunochim, F-38054 Grenoble 09, France
[2] Univ Paris 07, EA 3508, F-75251 Paris 05, France
[3] CePo Ctr Pluridsciplinaire Oncol, Lausanne, Switzerland
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2006年 / 40卷 / 11期
关键词：
Cu/Zn superoxide dismutase; Down syndrome; lymph nodes; reactive oxygen species; spleen; thymus; transgenic; T lymphocytes; free radicals;
D O I：
10.1016/j.freeradbiomed.2006.01.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previous studies have shown that transgenic mice overexpressing Cu/Zn superoxide dismutase, a model of Down syndrome, exhibit premature thymic involution. We have performed a flow cytometry analysis of the developing thymus in these homozygous transgenic mice (hSOD1/hSOD1: Tg-SOD). Longitudinal follow-up analysis from day 3 to day 280 showed an early thymic development in Tg-SOD mice compared with controls. This early thymic development was associated with an increased migration of mature T cells to peripheral lymphoid organs. BrdU labeling showed no difference between Tg-SOD and control mice, confirming that the greater number of peripheral T cells in Tg-SOD mice was not due to extensive proliferation of these cells but rather to a greater pool of emigrant T cells in Tg-SOD. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1971 / 1980
页数：10
相关论文
共 62 条
  • [1] Early block in maturation is associated with thymic involution in mammary tumor-bearing mice
    Adkins, B
    Charyulu, V
    Sun, QL
    Lobo, D
    Lopez, DM
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (11) : 5635 - 5640
  • [2] ARONSON M, 1991, THYMUS, V18, P7
  • [3] Aspinall R, 1997, J IMMUNOL, V158, P3037
  • [4] Longevity and the immune response
    Aspinall, R
    [J]. BIOGERONTOLOGY, 2000, 1 (03) : 273 - 278
  • [5] Proliferation, apoptosis and thymic involution
    Bar-Dayan, Y
    Afek, A
    Bar-Dayan, Y
    Goldberg, I
    Kopolovic, J
    [J]. TISSUE & CELL, 1999, 31 (04) : 391 - 396
  • [6] A central role for thymic emigrants in peripheral T cell homeostasis
    Berzins, SP
    Godfrey, DI
    Miller, JFAP
    Boyd, RL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) : 9787 - 9791
  • [7] Copper/zinc superoxide dismutase overexpression promotes survival of cortical neurons exposed to neurotoxins in vitro
    Borg, J
    London, J
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (02) : 180 - 189
  • [8] Oxidative modulation of nuclear factor-κB in human cells expressing mutant fALS-typical superoxide dismutases
    Casciati, A
    Ferri, A
    Cozzolino, M
    Celsi, F
    Nencini, M
    Rotilio, G
    Carrì, MT
    [J]. JOURNAL OF NEUROCHEMISTRY, 2002, 83 (05) : 1019 - 1029
  • [9] Chen YM, 2001, GLIA, V33, P343, DOI 10.1002/1098-1136(20010315)33:4<343::AID-GLIA1033>3.0.CO
  • [10] 2-H
1234567