Preparation of Hierarchical Hollow CaCO3 Particles and the Application as Anticancer Drug Carrier

被引：437

作者：

Wei, Wei ^{[1
]}

Ma, Guang-Hui ^{[1
]}

Hu, Gang ^{[2
]}

Yu, Di ^{[3
]}

Mcleish, Tom ^{[4
]}

Su, Zhi-Guo ^{[1
]}

Shen, Zhe-Yu ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China

[2] Unilever Res China, Shanghai 200233, Peoples R China

[3] Garvan Inst Med Res, Sydney, NSW 2010, Australia

[4] Univ Leeds, Sch Phys & Astron, Leeds LS2 9JT, W Yorkshire, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 47期

关键词：

D O I：

10.1021/ja8039585

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One-pot approach to couple the crystallization of CaCO3 nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.

引用

页码：15808 / +

页数：4

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