The Regulation of Cell Size

被引：292
作者：
Lloyd, Alison C. [1 ,2 ]
机构：
[1] UCL, MRC Lab Mol Cell Biol, London WC1E 6BT, England
[2] UCL, UCL Canc Inst, London WC1E 6BT, England
来源：
CELL | 2013年 / 154卷 / 06期
关键词：
SKELETAL-MUSCLE HYPERTROPHY; SACCHAROMYCES-CEREVISIAE; PROTEIN-SYNTHESIS; ORGAN SIZE; TRANSCRIPTION FACTORS; SIGNALING PATHWAY; UBIQUITIN LIGASES; MAMMALIAN-CELLS; GROWTH-CONTROL; CYCLE;
D O I：
10.1016/j.cell.2013.08.053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An adult animal consists of cells of vastly different size and activity, but the regulation of cell size remains poorly understood. Recent studies uncovering some of the signaling pathways important for size/growth control, together with the identification of diseases resulting from aberrations in these pathways, have renewed interest in this field. This Review will discuss our current understanding of how a cell sets its size, how it can adapt its size to a changing environment, and how these processes are relevant to human disease.
引用
收藏
页码：1194 / 1205
页数：12
相关论文
共 81 条
  • [1] VEGFR2 (KDR/Flk1) Signaling Mediates Axon Growth in Response to Semaphorin 3E in the Developing Brain
    Bellon, Anais
    Luchino, Jonathan
    Haigh, Katharina
    Rougon, Genevieve
    Haigh, Jody
    Chauvet, Sophie
    Mann, Fanny
    [J]. NEURON, 2010, 66 (02) : 205 - 219
  • [2] BIOLO G, 1995, AM J PHYSIOL, V268, P514
  • [3] Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
    Bodine, SC
    Stitt, TN
    Gonzalez, M
    Kline, WO
    Stover, GL
    Bauerlein, R
    Zlotchenko, E
    Scrimgeour, A
    Lawrence, JC
    Glass, DJ
    Yancopoulos, GD
    [J]. NATURE CELL BIOLOGY, 2001, 3 (11) : 1014 - 1019
  • [4] Identification of ubiquitin ligases required for skeletal muscle atrophy
    Bodine, SC
    Latres, E
    Baumhueter, S
    Lai, VKM
    Nunez, L
    Clarke, BA
    Poueymirou, WT
    Panaro, FJ
    Na, EQ
    Dharmarajan, K
    Pan, ZQ
    Valenzuela, DM
    DeChiara, TM
    Stitt, TN
    Yancopoulos, GD
    Glass, DJ
    [J]. SCIENCE, 2001, 294 (5547) : 1704 - 1708
  • [5] Fighting neurodegeneration with rapamycin: mechanistic insights
    Bove, Jordi
    Martinez-Vicente, Marta
    Vila, Miquel
    [J]. NATURE REVIEWS NEUROSCIENCE, 2011, 12 (08) : 437 - 452
  • [6] CELL-GROWTH, CELL-DIVISION AND CELL-SIZE HOMEOSTASIS IN SWISS 3T3-CELLS
    BROOKS, RF
    SHIELDS, R
    [J]. EXPERIMENTAL CELL RESEARCH, 1985, 156 (01) : 1 - 6
  • [7] Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy
    Castets, Perrine
    Lin, Shuo
    Rion, Nathalie
    Di Fulvio, Sabrina
    Romanino, Klaas
    Guridi, Maitea
    Frank, Stephan
    Tintignac, Lionel A.
    Sinnreich, Michael
    Rueegg, Markus A.
    [J]. CELL METABOLISM, 2013, 17 (05) : 731 - 744
  • [8] Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila
    Cheng, Louise Y.
    Bailey, Andrew P.
    Leevers, Sally J.
    Ragan, Timothy J.
    Driscoll, Paul C.
    Gould, Alex P.
    [J]. CELL, 2011, 146 (03) : 435 - 447
  • [9] Molecular mechanisms of axon guidance
    Chilton, JK
    [J]. DEVELOPMENTAL BIOLOGY, 2006, 292 (01) : 13 - 24
  • [10] Loss of Rb Cooperates with Ras to Drive Oncogenic Growth in Mammalian Cells
    Collins, Melissa J.
    Napoli, Ilaria
    Ribeiro, Sara
    Roberts, Sinead
    Lloyd, Alison C.
    [J]. CURRENT BIOLOGY, 2012, 22 (19) : 1765 - 1773
123456789