The Regulation of Cell Size

被引：296

作者：

Lloyd, Alison C. ^{[1
,2
]}

机构：

[1] UCL, MRC Lab Mol Cell Biol, London WC1E 6BT, England

[2] UCL, UCL Canc Inst, London WC1E 6BT, England

来源：

CELL | 2013年 / 154卷 / 06期

关键词：

SKELETAL-MUSCLE HYPERTROPHY; SACCHAROMYCES-CEREVISIAE; PROTEIN-SYNTHESIS; ORGAN SIZE; TRANSCRIPTION FACTORS; SIGNALING PATHWAY; UBIQUITIN LIGASES; MAMMALIAN-CELLS; GROWTH-CONTROL; CYCLE;

D O I：

10.1016/j.cell.2013.08.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An adult animal consists of cells of vastly different size and activity, but the regulation of cell size remains poorly understood. Recent studies uncovering some of the signaling pathways important for size/growth control, together with the identification of diseases resulting from aberrations in these pathways, have renewed interest in this field. This Review will discuss our current understanding of how a cell sets its size, how it can adapt its size to a changing environment, and how these processes are relevant to human disease.

引用

页码：1194 / 1205

页数：12

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