Delayed liver regeneration after partial hepatectomy in adiponectin knockout mice

被引：34
作者：
Ezaki, Hisao [1 ]
Yoshida, Yuichi [1 ]
Saji, Yukiko [1 ]
Takemura, Takayo [1 ]
Fukushima, Juichi [1 ]
Matsumoto, Hitoshi [1 ]
Kamada, Yoshihiro [1 ]
Wada, Akira [1 ]
Igura, Takumi [1 ]
Kihara, Shinji [2 ]
Funahashi, Tohru [2 ]
Shimomura, Iichiro [2 ]
Tamura, Shinji [1 ]
Kiso, Shinichi [1 ]
Hayashi, Norio [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Suita, Osaka 5650871, Japan
[2] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 378卷 / 01期
基金：
日本学术振兴会;
关键词：
Liver regeneration; Adiponectin; PPAR alpha; CPT-1; Fatty acid oxidation; PROLIFERATOR-ACTIVATED RECEPTOR; LIPID-METABOLISM; CAVEOLIN-1; DISEASE; INJURY; LEPTIN;
D O I：
10.1016/j.bbrc.2008.10.176
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We previously demonstrated that adiponectin has anti-fibrogenic and anti-inflammatory effects in the liver of mouse models of various liver diseases. However, its role in liver regeneration remains unclear. The aim of this study was to determine the role of adiponectin in liver regeneration. We assessed liver regeneration after partial hepatectomy in wild-type (WT) and adiponectin knockout (KO) mice. We analyzed DNA replication and various signaling pathways involved in cell proliferation and metabolism. Adiponectin KO mice exhibited delayed DNA replication and increased lipid accumulation in the regenerating liver. The expression levels of peroxisome proliferator-activated receptor (PPAR) alpha and carnitine palmitoyltransferase-1 (CPT-1), a key enzyme in mitochondrial fatty acid oxidation, were decreased in adiponectin KO mice, suggesting possible contribution of altered fat metabolism to these phenomena. Collectively, the present results highlight a new role for adiponectin in the Process of liver regeneration. (C) 2008 Elsevier Inc. All rights reserved
引用
收藏
页码：68 / 72
页数：5
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