NIR triggered liposome gold nanoparticles entrapping curcumin as in situ adjuvant for photothermal treatment of skin cancer

被引：83
作者：
Singh, Surya Prakash [1 ]
Alvi, Syed Baseeruddin [1 ]
Pemmaraju, Deepak Bharadwaj [1 ]
Singh, Anula Divyash [2 ]
Manda, Sasidhar Venkata [2 ]
Srivastava, Rohit [3 ]
Rengan, Aravind Kumar [1 ]
机构：
[1] Indian Inst Technol Hyderabad, Dept Biomed Engn, Kandi, Telangana, India
[2] Apollo Hosp Educ & Res Fdn, Hyderabad, Andhra Prades, India
[3] Indian Inst Technol, Dept Biosci & Bioengn, Bombay, Maharashtra, India
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 110卷
关键词：
Liposome gold nanoparticles; Curcumin; Photothermal adjuvant therapy; DRUG-DELIVERY SYSTEMS; SILICA NANOPARTICLES; BREAST-CANCER; CELLS; CHEMOTHERAPY; CYTOTOXICITY; STABILITY; PH; POLYMERSOMES; DEGRADATION;
D O I：
10.1016/j.ijbiomac.2017.11.163
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the synthesis of a biodegradable liposome gold nanoparticles for curcumin (Au-Lipos Cur NPs) delivery. This entrapped curcumin served as an in situ adjuvant for photothermal therapy. Curcumin was loaded in Au-Lipos NPs with an encapsulation efficiency of similar to 70%. The gold coating enabled the NPs to specifically absorb NIR light (780 nm) by virtue of Surface Plasmon Resonance (SPR) and this light energy was converted to heat. The generated heat destabilized the liposomal core enhancing the release of encapsulated curcumin. Photothermal transduction efficacy of Au-Lipos NPs (loaded with curcumin) showed a significant temperature rise upon laser irradiation causing irreversible cellular damage. In vitro photothermal effect and intracellular uptake was evaluated in B16 F10 (melanoma) cell line. Au-Lipos Cur NPs showed significantly enhanced uptake when compared with free curcumin. Enhancement in cancer cell cytotoxicity was observed in Au-Lipos Cur NPs treated group upon laser irradiation owing to curcumin. Our findings indicate that curcumin could serve as a potential in situ adjuvant for photothermal therapy of melanoma. (C) 2017 Elsevier B.V. All rights reserved.
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收藏
页码：375 / 382
页数：8
相关论文
共 41 条
[1]  
Aggarwal BB, 2003, ANTICANCER RES, V23, P363
[2]   Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation [J].
Ahmed, Fariyal ;
Pakunlu, Refika I. ;
Srinivas, Goundla ;
Brannan, Aaron ;
Bates, Frank ;
Klein, Michael L. ;
Minko, Tamara ;
Discher, Dennis E. .
MOLECULAR PHARMACEUTICS, 2006, 3 (03) :340-350
[3]  
Ali MFM, 2008, MED SCI MONITOR, V14, pPI66
[4]   Bioavailability of curcumin: Problems and promises [J].
Anand, Preetha ;
Kunnumakkara, Ajaikumar B. ;
Newman, Robert A. ;
Aggarwal, Bharat B. .
MOLECULAR PHARMACEUTICS, 2007, 4 (06) :807-818
[5]   Unusual seedless approach to gold nanoparticle synthesis: application to selective rapid naked eye detection of mercury(II) [J].
Anandhakumar, Sukeri ;
Rajaram, Rajendran ;
Mathiyarasu, Jayaraman .
ANALYST, 2014, 139 (13) :3356-3359
[6]   Does Delay of Adjuvant Chemotherapy Impact Survival in Patients With Resected Stage II and III Colon Adenocarcinoma? [J].
Bayraktar, Ulas Darda ;
Chen, Emerson ;
Bayraktar, Soley ;
Sands, Laurence R. ;
Marchetti, Floriano ;
Montero, Alberto Jose ;
Rocha-Lima, Caio Max S. .
CANCER, 2011, 117 (11) :2364-2370
[7]   Polymeric nanoparticle-encapsulated curcumin (nanocurcumin"): A novel strategy for human cancer therapy" [J].
Bisht S. ;
Feldmann G. ;
Soni S. ;
Ravi R. ;
Karikar C. ;
Maitra A. ;
Maitra A. .
Journal of Nanobiotechnology, 5 (1)
[8]   A Biocompatible Oxidation-Triggered Carrier Polymer with Potential in Therapeutics [J].
Broaders, Kyle E. ;
Grandhe, Sirisha ;
Frechet, Jean M. J. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (04) :756-758
[9]   Studies on curcumin and curcuminoids. XXIX. Photoinduced cytotoxicity of curcumin in selected aqueous preparations [J].
Bruzell, EM ;
Morisbak, E ;
Tonnesen, HH .
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2005, 4 (07) :523-530
[10]  
Das R.K., 2010, BIOL MED, V6
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