Epstein-Barr virus-derived EBNA2 regulates STAT3 activation

被引：32
|
作者：
Muromoto, Ryuta [1 ]
Ikeda, Osamu [1 ]
Okabe, Kanako [1 ]
Togi, Sumihito [1 ]
Kamitani, Shinya [1 ]
Fujimuro, Masahiro [2 ]
Harada, Shizuko [3 ]
Oritani, Kenji [4 ]
Matsud, Tadashi [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Immunol, Kita Ku, Kira 12 Nishi 6, Sapporo, Hokkaido 0600812, Japan
[2] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Mol Cell Biol, Chuo 4093898, Japan
[3] Natl Inst Infect Dis, Dept Virol 1, Shinjuku Ku, Tokyo 1628640, Japan
[4] Osaka Univ, Grad Sch Med, Dept Hematol & Oncol, Suita, Osaka 5650871, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 378卷 / 03期
关键词：
STAT3; EBV; EBNA2; LMP1; LIF; Transcription; FUNCTIONAL INTERACTIONS; TRANSCRIPTION FACTORS; BINDING-PROTEIN; LEUKEMIA-CELLS; J-KAPPA; GROWTH; DIFFERENTIATION; EXPRESSION; FAMILY; DNA;
D O I：
10.1016/j.bbrc.2008.11.053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Epstein-Barr virus (EBV)-encoded latency protein EBNA2 is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. Here, we show that EBNA2 interacts with STAT3, a signal transducer for an interleukin-6 family cytokine, and enhances the transcriptional activity of STAT3 by influencing its DNA-binding activity. Furthermore, EBNA2 cooperatively acts on STAT3 activation with LMP1, These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：439 / 443
页数：5
相关论文
共 50 条
  • [21] Detection of a nuclear antigen 2 (EBNA2)-variant Epstein-Barr virus strain in two siblings with fatal lymphoproliferative disease
    Schuster, V
    Seidenspinner, S
    Kreth, HW
    JOURNAL OF MEDICAL VIROLOGY, 1996, 48 (01) : 114 - 120
  • [22] Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma
    Sivachandran, Nirojini
    Dawson, Christopher W.
    Young, Lawrence S.
    Liu, Fei-Fei
    Middeldorp, Jaap
    Frappier, Lori
    JOURNAL OF VIROLOGY, 2012, 86 (01) : 60 - 68
  • [23] Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes
    Yenamandra, Surya Pavan
    Hellman, Ulf
    Kempkes, Bettina
    Darekar, Suhas Deoram
    Petermann, Sabine
    Sculley, Tom
    Klein, George
    Kashuba, Elena
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2010, 67 (24) : 4249 - 4256
  • [24] Interleukin-21 regulates expression of key Epstein-Barr virus oncoproteins, EBNA2 and LMP1, in infected human B cells
    Konforte, Danijela
    Simard, Nathalie
    Paige, Christopher J.
    VIROLOGY, 2008, 374 (01) : 100 - 113
  • [25] STAT3 as a therapeutic target for Epstein-Barr virus (EBV) - associated nasopharyngeal carcinoma
    Ho, Yeung
    Tsao, Sai-Wah
    Zeng, Musheng
    Lui, Vivian Wai Yan
    CANCER LETTERS, 2013, 330 (02) : 141 - 149
  • [26] Structure and function of the Epstein-Barr virus transcription factor, EBNA 3C
    West, MJ
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2006, 7 (02) : 123 - 136
  • [27] Regulation of transcription by the Epstein-Barr virus nuclear antigen EBNA 2
    Palermo, Richard D.
    Webb, Helen M.
    Gunnell, Andrea
    West, Michelle J.
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 : 625 - 628
  • [28] Epstein-Barr virus EBNA2 directs doxorubicin resistance of B cell lymphoma through CCL3 and CCL4-mediated activation of NF-κB and Btk
    Kim, Joo Hyun
    Kim, Won Seog
    Hong, Jung Yong
    Ryu, Kung Ju
    Kim, Seok Jin
    Park, Chaehwa
    ONCOTARGET, 2017, 8 (03) : 5361 - 5370
  • [29] The amino acid region 248-382 of the Epstein-Barr virus nuclear protein 2 (EBNA2) is responsible for the EBNA2-induced EBV reactivation
    Fujiwara, S
    Liu, EG
    Shimizu, K
    VIRUS GENES, 2001, 23 (03) : 361 - 365
  • [30] BS69 negatively regulates the canonical NF-κB activation induced by Epstein-Barr virus-derived LMP1
    Ikeda, Osamu
    Sekine, Yuichi
    Mizushima, Akihiro
    Oritani, Kenji
    Yasui, Teruhito
    Fujimuro, Masahiro
    Muromoto, Ryuta
    Nanbo, Asuka
    Matsuda, Tadashi
    FEBS LETTERS, 2009, 583 (10) : 1567 - 1574
12345