Catalyst-free one-pot synthesis of isoindolin-1-imine derivatives via three-component reaction

被引：7

作者：

Shen, Sida ^{[1
]}

Pham Van Khang ^{[1
]}

Chen, Yijia ^{[2
]}

Lei, Min ^{[2
]}

Hu, Lihong ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China

来源：

ARKIVOC | 2013年

基金：

中国国家自然科学基金;

关键词：

2-cyanobenzaldehyde; 3-methyl-1H-pyrazol-5(4H)-one; 1,3-dimethyl-1H-pyrazol-5(4H)-one; isoindolin-1-imine; multi-component reaction; 2-CYANOBENZALDEHYDE;

D O I：

10.3998/ark.5550190.p007.992

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, one-pot method has been developed for the synthesis of 4-(2-substituented-3-iminoisoindolin-1-ylidene)-1-substitueted-3-methyl-1H-pyrazol-5(4H)-one derivatives via cascade three-component condensation of 2-cyanobenzaldehyde, amine, and 3-methyl-1H-pyrazol-5(4H)-one or 1,3-dimethyl-1H-pyrazol-5(4H)-one. The efficient and convenient reaction conditions provide the corresponding products from various substrates under reflux condition in ethanol with excellent yields (85-95%).

引用

页码：413 / 423

页数：11

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