Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo

被引:19
|
作者
Soderquist, R. [1 ,2 ]
Bates, D. J. P. [1 ,2 ]
Danilov, A. V. [2 ,3 ]
Eastman, A. [1 ,2 ]
机构
[1] Giesel Sch Med Dartmouth, Dept Pharmacol & Toxicol, Lebanon, NH USA
[2] Giesel Sch Med Dartmouth, Norris Cotton Canc Ctr, Lebanon, NH USA
[3] Giesel Sch Med Dartmouth, Dept Med, Lebanon, NH USA
关键词
NAVITOCLAX; EXPRESSION; APOPTOSIS; PROTEINS; ABT-263; POTENT;
D O I
10.1038/leu.2013.138
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:2262 / 2264
页数:4
相关论文
共 50 条
  • [31] ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
    M P Kline
    S V Rajkumar
    M M Timm
    T K Kimlinger
    J L Haug
    J A Lust
    P R Greipp
    S Kumar
    Leukemia, 2007, 21 : 1549 - 1560
  • [32] Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells
    Purroy, Noelia
    Carabia, Julia
    Abrisqueta, Pau
    Egia, Leire
    Aguilo, Meritxell
    Carpio, Cecilia
    Palacio, Carles
    Crespo, Marta
    Bosch, Francesc
    ONCOTARGET, 2017, 8 (01) : 742 - 756
  • [33] Effective cell killing of primary acute lymphoblastic leukemia cells by the BCL-2 antagonist ABT-737
    Tafuri, A.
    Ricciardi, M. R.
    Gregorj, C.
    De Cave, F.
    Santinelli, S.
    Bergamo, P.
    Decandia, S.
    Vitale, A.
    Petrucci, M. T.
    Milella, M.
    Foa, R.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 5 - 6
  • [34] ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
    Kline, M. P.
    Rajkumar, S. V.
    Timm, M. M.
    Kimlinger, T. K.
    Haug, J. L.
    Lust, J. A.
    Greipp, P. R.
    Kumar, S.
    LEUKEMIA, 2007, 21 (07) : 1549 - 1560
  • [35] The pan-Bcl-2 family inhibitor ABT-737 synergizes with DNA damaging agents by enhancing apoptosis in acute lymphoblastic leukemia cells
    Bang, Sookhee
    Kang, Yun Hee
    Reynolds, Charles
    Kang, Min
    CANCER RESEARCH, 2009, 69
  • [36] VSV Oncolysis in Combination With the BCL-2 Inhibitor Obatoclax Overcomes Apoptosis Resistance in Chronic Lymphocytic Leukemia
    Samuel, Sara
    Tumilasci, Vanessa F.
    Oliere, Stephanie
    Nguyen, Thi Lien-Anh
    Shamy, April
    Bell, John
    Hiscott, John
    MOLECULAR THERAPY, 2010, 18 (12) : 2094 - 2103
  • [37] Induction of oxidative stress and glutathione depletion by ABT-737, a novel small molecule inhibitor of Bcl-2, contributes to cytotoxicity in leukemia cells
    Chandra, Joya
    Howard, Adrienne
    Jensen, Kathleen
    Meyn, Ray
    BLOOD, 2007, 110 (11) : 152B - 152B
  • [38] Ex vivo activity of BCL-2 family inhibitors ABT-199 and ABT-737 combined with 5-azacytidine in myeloid malignancies
    Bogenberger, James M.
    Delman, Devora
    Hansen, Nanna
    Valdez, Riccardo
    Fauble, Veena
    Mesa, Ruben A.
    Tibes, Raoul
    LEUKEMIA & LYMPHOMA, 2015, 56 (01) : 226 - 229
  • [39] Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: In vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737
    Ishitsuka, Kenji
    Kunami, Naoko
    Katsuya, Hiroo
    Nogami, Rumiko
    Ishikawa, Chie
    Yotsumoto, Fusanori
    Tanji, Hiroe
    Mori, Naoki
    Takeshita, Morishige
    Miyamoto, Shingo
    Tamura, Kazuo
    CANCER LETTERS, 2012, 317 (02) : 218 - 225
  • [40] Combined targeting of MCL1 with TG02 and BCL2 with ABT-737/ABT-199 as a strategy for eliminating AML cells
    Yu, N.
    Abdul-Aziz, A.
    Burrows, F.
    Russell, N.
    Seedhouse, C.
    Pallis, M.
    BRITISH JOURNAL OF HAEMATOLOGY, 2013, 161 : 58 - 58