The value of antimicrobial peptides in the age of resistance

被引：743

作者：

Magana, Maria ^{[1
]}

Pushpanathan, Muthuirulan ^{[2
]}

Santos, Ana L. ^{[3
,4
]}

Leanse, Leon ^{[5
,6
]}

Fernandez, Michael ^{[7
]}

Ioannidis, Anastasios ^{[8
]}

Giulianotti, Marc A. ^{[9
]}

Apidianakis, Yiorgos ^{[10
]}

Bradfute, Steven ^{[11
]}

Ferguson, Andrew L. ^{[12
]}

Cherkasov, Artem ^{[7
]}

Seleem, Mohamed N. ^{[13
]}

Pinilla, Clemencia ^{[9
]}

de la Fuente-Nunez, Cesar ^{[14
,15
,16
]}

Lazaridis, Themis ^{[17
,18
,19
,20
]}

Dai, Tianhong ^{[5
,6
]}

Houghten, Richard A. ^{[9
]}

Hancock, Robert E. W. ^{[21
]}

Tegos, George P. ^{[22
,23
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Dept Biopathol & Clin Microbiol, Aeginit Hosp, Sch Med, Athens, Greece

[2] Harvard Univ, Dept Human Evolutionary Biol, Cambridge, MA 02138 USA

[3] Rice Univ, Dept Chem, Houston, TX USA

[4] Invest Sanitaria Islas Baleares, Palma De Mallorca, Spain

[5] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA

[6] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[7] Univ British Columbia, Vancouver Prostate Ctr, Dept Urol Sci, Vancouver, BC, Canada

[8] Univ Peloponnese, Dept Nursing, Sparta, Greece

[9] Torrey Pines Inst Mol Studies, Port St Lucie, FL USA

[10] Univ Cyprus, Dept Biol Sci, Nicosia, Cyprus

[11] Univ New Mexico, Dept Internal Med, Ctr Global Hlth, Albuquerque, NM 87131 USA

[12] Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 USA

[13] Purdue Univ, Dept Comparat Pathobiol, Coll Vet Med, W Lafayette, IN 47907 USA

[14] Univ Penn, Inst Translat Med & Therapeut, Machine Biol Grp,Penn Inst Computat Sci, Dept Psychiat,Inst Biomed Informat,Perelman Sch M, Philadelphia, PA USA

[15] Univ Penn, Inst Translat Med & Therapeut, Machine Biol Grp,Penn Inst Computat Sci, Dept Microbiol,Inst Biomed Informat,Perelman Sch, Philadelphia, PA USA

[16] Univ Penn, Dept Bioengn, Philadelphia, PA USA

[17] CUNY City Coll, Dept Chem, New York, NY USA

[18] CUNY, Grad Ctr, Grad Program Chem, New York, NY USA

[19] CUNY, Grad Ctr, Grad Program Biochem, New York, NY USA

[20] CUNY, Grad Ctr, Grad Program Phys, New York, NY USA

[21] Univ British Columbia, Dept Microbiol & Immunol, Ctr Microbial Dis & Immun Res, Vancouver, BC, Canada

[22] Reading Hosp, Tower Hlth, W Reading, PA 19611 USA

[23] Venture X Marlborough, Micromoria, Marlborough, MA USA

来源：

LANCET INFECTIOUS DISEASES | 2020年 / 20卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MEMBRANE-ACTIVE PEPTIDES; HOST-DEFENSE PEPTIDES; FORMS ION CHANNELS; BROAD-SPECTRUM; BIOFILM FORMATION; IN-VITRO; ANTIBACTERIAL PEPTIDES; BIOLOGICAL-ACTIVITY; CHIMERIC PEPTIDES; GRAMICIDIN-S;

D O I：

10.1016/S1473-3099(20)30327-3

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Accelerating growth and global expansion of antimicrobial resistance has deepened the need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear advantages over conventional antibiotics which include slower emergence of resistance, broad-spectrum antibiofilm activity, and the ability to favourably modulate the host immune response. Broad bacterial susceptibility to antimicrobial peptides offers an additional tool to expand knowledge about the evolution of antimicrobial resistance. Structural and functional limitations, combined with a stricter regulatory environment, have hampered the clinical translation of antimicrobial peptides as potential therapeutic agents. Existing computational and experimental tools attempt to ease the preclinical and clinical development of antimicrobial peptides as novel therapeutics. This Review identifies the benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens, highlights advances in the deployment of novel promising antimicrobial peptides, and underlines the needs and priorities in designing focused development strategies taking into account the most advanced tools available.

引用

页码：E216 / E230

页数：15

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