Researchers have well established the association between discriminatory experiences, life chances, and mental health outcomes among Latino/as, especially among Mexican Americans. However, few studies have focused on the impact of stress or the moderating effects of low acculturation levels among recent immigrants, such as Dominicans. Using the transactional stress model, the present community-based study examines the relationship between discrimination and stress, and whether this association varies by low acculturation levels in a sample of 246 Dominican women. Results indicate a positive relationship between major racist events (e. g., job-related discrimination), everyday discrimination (e. g., not receiving services in a store), and stress levels. Furthermore, low acculturation moderated the impact that discriminatory experiences had on the stress level of Dominican women. Implications for further research on discrimination and stress among Dominican immigrants are discussed.