Chemical Constituents of the Sponge Mycale Species from South China Sea

被引：0

作者：

Zhou, Xuefeng ^{[1
]}

Lin, Xiuping ^{[1
]}

Guo, Xieyang ^{[2
]}

Yang, Bin ^{[1
]}

Yang, Xian-Wen ^{[1
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, South China Sea Inst Oceanol, Res Ctr Marine Microbes, Guangdong Key Lab Marine Mat Med,Key Lab Marine B, Guangzhou 510301, Guangdong, Peoples R China

[2] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2013年 / 7卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Sponge Mycale species; Chemical constituents; Brine shrimp lethality test; MARINE SPONGE; STEROLS; METABOLITES;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the sponge Mycale species from the South China Sea afforded eleven known compounds, henicosanoic acid methyl ester (1), hexadecyl ethers of glycerol (2), N-docosanoyl-D-erythro-(2S,3R)-16-methyl-heptadecasphing-4(E)-enine (3), dibutyl phthalate (4), cholesterol (5), 5 alpha,8 alpha-epidioxycholest-6,22-dien-3 beta-ol (6), 5-hexadecyl-pyrrole-2-carboxaldehyde (7), benzoic acid (8), 4-hydroxybenzoic acid (9), thymine (10), and uracil (11) Compounds 1-4, 6-9 were obtained from the sponge of the genus Mycale for the first time, and 4 and 6 showed toxicity in the brine shrimp lethality test with the LD50 values at 2.9 mu g/mL and 4.7 mu g/mL, respectively.

引用

页码：119 / 123

页数：5

共 23 条

[1] 1,5-Diazacyclohenicosane, a New Cytotoxic Metabolite from the Marine Sponge Mycale sp. [J].