Coupling of folding and binding for unstructured proteins

被引：1111
|
作者：
Dyson, HJ
Wright, PE
机构：
[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0959-440X(02)00289-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There are now numerous examples of proteins that are unstructured or only partially structured under physiological conditions and yet are nevertheless functional. Such proteins are especially prevalent in eukaryotes. In many cases, intrinsically disordered proteins adopt folded structures upon binding to their biological targets. Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition.
引用
收藏
页码：54 / 60
页数：7
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