Coupling of folding and binding for unstructured proteins

被引：1115
作者：
Dyson, HJ
Wright, PE
机构：
[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0959-440X(02)00289-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There are now numerous examples of proteins that are unstructured or only partially structured under physiological conditions and yet are nevertheless functional. Such proteins are especially prevalent in eukaryotes. In many cases, intrinsically disordered proteins adopt folded structures upon binding to their biological targets. Many new examples of coupled folding and binding events have been reported recently, providing new insights into mechanisms of molecular recognition.
引用
收藏
页码：54 / 60
页数：7
相关论文
共 60 条
[1]   Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein [J].
Abdul-Manan, N ;
Aghazadeh, B ;
Liu, GA ;
Majumdar, A ;
Ouerfelli, O ;
Siminovitch, KA ;
Rosen, MK .
NATURE, 1999, 399 (6734) :379-383
[2]   Structure of the S15,S18-rRNA complex: Assembly of the 30S ribosome central domain [J].
Agalarov, SC ;
Prasad, GS ;
Funke, PM ;
Stout, CD ;
Williamson, JR .
SCIENCE, 2000, 288 (5463) :107-112
[3]  
Aivazian D, 2000, NAT STRUCT BIOL, V7, P1023
[4]   Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin [J].
Allain, FHT ;
Bouvet, P ;
Dieckmann, T ;
Feigon, J .
EMBO JOURNAL, 2000, 19 (24) :6870-6881
[5]   Latent and active p53 are identical in conformation [J].
Ayed, A ;
Mulder, FAA ;
Yi, GS ;
Lu, Y ;
Kay, LE ;
Arrowsmith, CH .
NATURE STRUCTURAL BIOLOGY, 2001, 8 (09) :756-760
[6]   Binding of elongin A or a von Hippel-Lindau peptide stabilizes the structure of yeast elongin C [J].
Botuyan, MV ;
Koth, CM ;
Mer, G ;
Chakrabartty, A ;
Conaway, JW ;
Conaway, RC ;
Edwards, AM ;
Arrowsmith, CH ;
Chazin, WJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :9033-9038
[7]   Solution structure and dynamics of yeast elongin C in complex with a von Hippel-Lindau peptide [J].
Botuyan, MV ;
Mer, G ;
Yi, GS ;
Koth, CM ;
Case, DA ;
Edwards, AM ;
Chazin, WJ ;
Arrowsmith, CH .
JOURNAL OF MOLECULAR BIOLOGY, 2001, 312 (01) :177-186
[8]   Recognition of pre-formed and flexible elements of an RNA stem-loop by nucleolin [J].
Bouvet, P ;
Allain, FHT ;
Finger, LD ;
Dieckmann, T ;
Feigon, J .
JOURNAL OF MOLECULAR BIOLOGY, 2001, 309 (03) :763-775
[9]  
Bowers PW, 1999, NAT STRUCT BIOL, V6, P478
[10]   Biophysical characterization of elongin C from Saccharomyces cerevisiae (vol 39, pg 11137, 2000) [J].
Buchberger, A ;
Howard, MJ ;
Freund, SMV ;
Proctor, M ;
Butler, PJG ;
Fersht, AR ;
Bycroft, M .
BIOCHEMISTRY, 2000, 39 (40) :12512-12512
123456