Fluorescent Polymeric Micelles with Aggregation-Induced Emission Properties for Monitoring the Encapsulation of Doxorubicin

被引：40

作者：

Chen, Jen-Ing ^{[1
]}

Wu, Wen-Chung ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Dept Chem Engn, Tainan 70101, Taiwan

来源：

MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 05期

关键词：

aggregation-induced emission; drug carriers; fluorescence; micelles; optical imaging; BLOCK-COPOLYMER MICELLES; ANTICANCER DRUG; DELIVERY-SYSTEM; CANCER; NANOPARTICLES; MICELLIZATION; FLUOROPHORES; RELEASE;

D O I：

10.1002/mabi.201200396

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new type of fluorescent polymeric micelles is developed by self-assembly from a series of amphiphilic block copolymers, poly(ethylene glycol)-b-poly[styrene-co-(2-(1,2,3,4,5-pentaphenyl-1H-silol-1-yloxy)ethyl methacrylate)] [PEG-b-P(S-co-PPSEMA)]. Their capability of loading doxorubicin (DOX) is investigated by monitoring the loading content, encapsulation efficiency, and photophysical properties of micelles. Forster resonance energy transfer from PPSEMA to DOX is observed in DOX-loaded micelles, which can serve as an indication of successful encapsulation of DOX in these micelles. The application of this new type of fluorescent polymeric micelles as a fluorescent probe and an anticancer drug carrier simultaneously is explored by studying the intracellular uptake of DOX-loaded micelles.

引用

页码：623 / 632

页数：10

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