Nicotinamide inhibits inducible nitric oxide synthase mRNA in primary rat glial cells

被引：18

作者：

Fujimura, M ^{[1
]}

Tominaga, T ^{[1
]}

Yoshimoto, T ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT NEUROSURG,AOBA KU,SENDAI,MIYAGI 98077,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 228卷 / 02期

关键词：

nitric oxide; nitric oxide synthase; inducible nitric oxide synthase; nicotinamide; glial cells; lipopolysaccharide; interferon-gamma; poly (ADP-ribose) synthetase;

D O I：

10.1016/S0304-3940(97)00373-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide (NO) exerts cytotoxic effects on various cells including neuronal cells. Glial NO production, mediated via induction of inducible NO synthase (iNOS), enhances neurotoxicity associated with the N-methyl-D-aspartate (NMDA) receptor. The present study examined whether nicotinamide, an inhibitor of poly (ADP-ribose) synthetase, inhibits NO formation in primary culture of rat glial cells. Nicotinamide (5-20 mM) suppressed iNOS mRNA expression and subsequent NO formation, which were induced by the combination of interferon-gamma and lipopolysaccharide, in a dose dependent manner. In addition, high-concentration (20 mM) nicotinamide decreased mRNA of interferon regulatory factor-1, a transcription factor which plays a major role in iNOS mRNA induction. These results suggest that nicotinamide may have protective effect on glial NO-related pathologies by preventing iNOS mRNA induction. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：107 / 110

页数：4

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