Synthesis of enantiopure β2-homoalanine derivatives via rhodium catalyzed asymmetric hydrogenation

被引：5

作者：

Luehr, Susan ^{[1
]}

Holz, Jens ^{[1
]}

Zayas, Odalys ^{[2
]}

Seidelmann, Oliver ^{[3
]}

Domke, Lutz ^{[1
]}

Boerner, Armin ^{[1
,2
]}

机构：

[1] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany

[2] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[3] ChiroBlock GmbH, D-06766 Wolfen, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2013年 / 24卷 / 07期

关键词：

BETA-AMINO ACIDS; R-SMS-PHOS; ENANTIOSELECTIVE SYNTHESIS; BETA(2)-AMINO ACIDS; STEREOSELECTIVE HYDROGENATION; KINETIC RESOLUTION; LIGANDS; ACRYLATES; CYCLAMENOL; ADDITIONS;

D O I：

10.1016/j.tetasy.2013.02.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The stereoselective synthesis of chiral beta(2)-homoalanine derivatives with 99% ee by the Rh-catalyzed enantioselective hydrogenation of prochiral 2-aminomethyl acrylates is described. The subsequent transformation to chiral 3-amino-2-methylpropanols is also demonstrated. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：395 / 401

页数：7

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