Synthesis of enantiopure β2-homoalanine derivatives via rhodium catalyzed asymmetric hydrogenation

被引：5
作者：
Luehr, Susan [1 ]
Holz, Jens [1 ]
Zayas, Odalys [2 ]
Seidelmann, Oliver [3 ]
Domke, Lutz [1 ]
Boerner, Armin [1 ,2 ]
机构：
[1] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany
[2] Univ Rostock, Inst Chem, D-18059 Rostock, Germany
[3] ChiroBlock GmbH, D-06766 Wolfen, Germany
来源：
TETRAHEDRON-ASYMMETRY | 2013年 / 24卷 / 07期
关键词：
BETA-AMINO ACIDS; R-SMS-PHOS; ENANTIOSELECTIVE SYNTHESIS; BETA(2)-AMINO ACIDS; STEREOSELECTIVE HYDROGENATION; KINETIC RESOLUTION; LIGANDS; ACRYLATES; CYCLAMENOL; ADDITIONS;
D O I：
10.1016/j.tetasy.2013.02.011
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The stereoselective synthesis of chiral beta(2)-homoalanine derivatives with 99% ee by the Rh-catalyzed enantioselective hydrogenation of prochiral 2-aminomethyl acrylates is described. The subsequent transformation to chiral 3-amino-2-methylpropanols is also demonstrated. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：395 / 401
页数：7
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