Revisiting the Hirao cross-coupling: improved synthesis of aryl and heteroaryl phosphonates

被引：126

作者：

Belabassi, Yamina ^{[1
]}

Alzghari, Saeed ^{[1
]}

Montchamp, Jean-Luc ^{[1
]}

机构：

[1] Texas Christian Univ, Dept Chem, Ft Worth, TX 76129 USA

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2008年 / 693卷 / 19期

关键词：

cross-coupling; phosphorus; palladium; heterocycles; aryl halides;

D O I：

10.1016/j.jorganchem.2008.07.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The palladium-catalyzed cross-coupling of dialkylphosphite with aromatic electrophiles (Hirao coupling) was re-investigated. Some limitations in terms of palladium loadings and substrate reactivity are alleviated with the use of Pd(OAc)(2) complexed to 1,1'-bis(diphenylphosphino) ferrocene (dppf) as a ligand. Various aryl and heteroaryl halides are employed to deliver both known and novel substituted phosphonates. The first examples of aryl chloride couplings are also reported. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：3171 / 3178

页数：8

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