microRNAs and thyroid cancer: Biological and clinical significance

被引：37

作者：

Leonardi, Giulia Costanza ^{[1
]}

Candido, Saverio ^{[1
]}

Carbone, Maurizio ^{[2
]}

Colaianni, Valeria ^{[2
]}

Garozzo, Sebastiano F. ^{[2
]}

Cina, Diana ^{[2
]}

Libra, Massimo ^{[1
]}

机构：

[1] Univ Catania, Lab Translat Oncol & Funct Genom, Sect Pathol & Oncol, Dept Biomed Sci, I-95124 Catania, Italy

[2] Garibaldi Hosp, Clin Pathol Lab, Catania, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2012年 / 30卷 / 05期

关键词：

thyroid cancer; microRNA; biomarkers; NUCLEAR EXPORT; SMALL RNAS; DIFFERENTIAL EXPRESSION; PAPILLARY CARCINOMAS; DOWN-REGULATION; LET-7; MICRORNA; BRAF MUTATIONS; CELL-GROWTH; GENE; MIRNAS;

D O I：

10.3892/ijmm.2012.1089

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Despite recent advances in the management of thyroid cancer, he survival rate of this tumor may still be improved. Therefore, the identification of biological and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-risk lesions. microRNAs (miRNAs) are small RNA molecules with regulatory function and marked tissue specificity that modulate multiple targets belonging to several pathways. They are frequently deregulated in cancer and constitute a new class of blood-based biomarkers useful for cancer detection and prognosis definition, including thyroid cancer. In this review, the role of miRNAs in thyroid cancer development is described. The most common miRNAs detected in thyroid cancer along with their clinical significance are also discussed. Further studies aimed to detect plasma-based miRNA biomarkers in thyroid cancer patients may provide further insight into the management of thyroid cancer.

引用

页码：991 / 999

页数：9

共 89 条

[1] MicroRNA Profiling of Sporadic and Hereditary Medullary Thyroid Cancer Identifies Predictors of Nodal Metastasis, Prognosis, and Potential Therapeutic Targets [J].