Emergence of Foot-and-Mouth Disease Virus SAT 2 in Egypt During 2012

被引：83

作者：

Ahmed, H. A. ^{[2
]}

Salem, S. A. H. ^{[2
]}

Habashi, A. R. ^{[2
]}

Arafa, A. A. ^{[2
]}

Aggour, M. G. A. ^{[2
]}

Salem, G. H. ^{[2
]}

Gaber, A. S. ^{[2
]}

Selem, O. ^{[3
]}

Abdelkader, S. H. ^{[3
]}

Knowles, N. J. ^{[1
]}

Madi, M. ^{[1
]}

Valdazo-Gonzalez, B. ^{[1
]}

Wadsworth, J. ^{[1
]}

Hutchings, G. H. ^{[1
]}

Mioulet, V. ^{[1
]}

Hammond, J. M. ^{[1
]}

King, D. P. ^{[1
]}

机构：

[1] Inst Anim Hlth, Pirbright GU24 0NF, England

[2] Anim Hlth Res Inst, Dokki Giza, Egypt

[3] Gen Org Vet Serv, Dokki Giza, Egypt

来源：

TRANSBOUNDARY AND EMERGING DISEASES | 2012年 / 59卷 / 06期

关键词：

epidemiology; sequencing; foot-and-mouth disease; Egypt; real-time RT-PCR; MOLECULAR CHARACTERIZATION; DIAGNOSIS; SEROTYPE; ASSAY;

D O I：

10.1111/tbed.12015

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The epidemiology of foot-and-mouth disease (FMD) in North Africa is complicated by the co-circulation of endemic FMD viruses (FMDV), as well as sporadic incursions of exotic viral strains from the Middle East and Sub-Saharan Africa. This report describes the molecular characterization of SAT 2 FMD viruses that have caused widespread field outbreaks of FMD in Egypt during February and March 2012. Phylogenetic analysis showed that viruses from these outbreaks fell into two distinct lineages within the SAT 2 topotype VII, which were distinct from a contemporary SAT 2 lineage of the same toptype from Libya. These were the first FMD outbreaks due to this serotype in Egypt since 1950 and required the development of a tailored real-time reverse-transcription PCR assay that can be used in the laboratory to distinguish FMD viruses of these lineages from other endemic FMD viruses that might be present in North Africa. These data highlight the ease by which FMDV can cross international boundaries and emphasize the importance of deploying systems to continuously monitor the global epidemiology of this disease.

引用

页码：476 / 481

页数：6

共 20 条

[1] The implications of virus diversity within the SAT 2 serotype for control of foot-and-mouth disease in sub-Saharan Africa [J].