Involvement of neuromedin S in the oxytocin release response to suckling stimulus

被引：17

作者：

Sakamoto, Takumi ^{[1
]}

Mori, Kenji ^{[2
]}

Miyazato, Mikiya ^{[2
]}

Kangawa, Kenji ^{[2
]}

Sameshima, Hiroshi ^{[3
]}

Nakahara, Keiko ^{[1
]}

Murakami, Noboru ^{[1
]}

机构：

[1] Miyazaki Univ, Fac Agr, Dept Vet Physiol, Miyazaki 8892155, Japan

[2] Natl Cardiovasc Ctr, Res Inst, Dept Biochem, Osaka 5658565, Japan

[3] Miyazaki Univ, Fac Agr, Dept Obstet & Gynecol, Miyazaki 8892192, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 375卷 / 01期

关键词：

neuromedin S; oxytocin; suckling; milk ejection;

D O I：

10.1016/j.bbrc.2008.07.124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We recently identified neuromedin S (NMS) from the rat hypothalamus as an endogenous ligand for the FM-4/TGR-1 receptor distinct from neuromedin U. In the present study we examined the role of NMS in, the oxytocin release response to suckling stimulation by rat pups. Intracerebroventricular (icv) injection of NMS induced cFos expression in the paraventricular nucleus and supraoptic nucleus. Double immunohistochemical analysis revealed induction of cFos expression in a proportion of oxytocinergic neurons in both nuclei. In addition, icv injection of NMS stimulated oxytocin release close-dependently in intact rats, and increased milk secretion in lactating rats. On the other hand, icv injection of anti-NMS antiserum into lactating rats significantly suppressed suckling-induced milk ejection. These results Suggest that, in the rat, endogenous NMS plays an important role in the oxytocin release response to the suckling stimulus. (C) 2008 Published by Elsevier Inc.

引用

页码：49 / 53

页数：5

共 48 条

[41] Child's oxytocin response to mother-child interaction: The contribution of child genetics and maternal behavior
Baiao, Rita
Fearon, Pasco
Belsky, Jay
Baptista, Joana
Carneiro, Alexandra
Pinto, Raquel
Nogueira, Marlene
Oliveira, Cesar
Soares, Isabel
Mesquita, Ana R.
[J]. PSYCHONEUROENDOCRINOLOGY, 2019, 102 : 79 - 83
[42] Oxytocin-stimulated insulin release in a clonal beta-cell line RINm5F: Involvement of phospholipase C-dependent and -independent pathways
Lee, BS
Chen, TH
Hsu, WH
[J]. ACTA PHARMACOLOGICA SINICA, 1996, 17 (05): : 390 - 394
[43] Effects of arginine vasopressin and oxytocin on glucagon release from clonal α-cell line In-R1-G9:: Involvement of V1b receptors
Yibchok-anun, S
Hsu, WH
[J]. LIFE SCIENCES, 1998, 63 (21) : 1871 - 1878
[44] Inpatient's, therapist's and staff's expectations regarding treatment and their effects on placebo response in the psychiatric ward - results from an add-on oxytocin RCT
Nitzan, Uri
Grossman-Girron, A.
Sedoff, O.
Maoz, H.
Arad, O.
Tilbor, E.
Dror, C.
Bitan, D. Tzur
[J]. PSYCHOPHARMACOLOGY, 2024, 241 (09) : 1781 - 1789
[45] Men's sexual response to female partner's intranasal oxytocin administration for hypoactive sexual desire disorder: an open prospective cohort study
Muin, Dana A.
Rezaei, Safoura Sheikh
Tremmel-Scheinost, Max
Salama, Mohamed
Luger, Anton
Wolzt, Michael
Husslein, Peter W.
Bayerle-Eder, Michaela
[J]. FERTILITY AND STERILITY, 2017, 107 (03) : 781 - +
[46] Glutamate receptor antagonist infused into the hypothalamic suprachiasmatic nuclei interferes with the diurnal fluctuations in plasma prolactin and corticosterone levels and injected into the mesencephalic dorsal raphe nucleus attenuates the suckling stimulus-induced release of prolactin of the rat
Bodnar, Ibolya
Banky, Zsuzsanna
Zelena, Dora
Halasz, Bela
[J]. BRAIN RESEARCH BULLETIN, 2009, 80 (1-2) : 9 - 16
[47] ABLATION OF THE REGION ANTERIOR AND VENTRAL TO THE 3RD VENTRICLE (AV3V REGION) IN THE RAT DOES NOT ABOLISH THE RELEASE OF OXYTOCIN IN RESPONSE TO SYSTEMIC CHOLECYSTOKININ
BLACKBURN, RE
LENG, G
[J]. BRAIN RESEARCH, 1990, 508 (01) : 156 - 160
[48] Oxytocin Anti-Apoptotic Potential Mediates Neuroprotection Against 3-Nitropropionic Acid-Induced Huntington’s Disease-Like Pathophysiology in Rats: Involvement of Calpain-2/p25 Cdk5/MEF-2 Signaling Pathway
Marwa Rabie
Dalia M. El-Tanbouly
Esraa A. Kandil
Helmy M. Sayed
[J]. Neurochemical Research, 2025, 50 (3)

← 1 2 3 4 5 →