Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner

被引：14

作者：

Lee, Mi Eun ^{[1
]}

Kim, So Ra ^{[1
]}

Lee, Seungkoo ^{[2
]}

Jung, Yu-Jin ^{[3
]}

Choi, Sun Shim ^{[4
]}

Kim, Woo Jin ^{[5
]}

Han, Jeong A. ^{[1
]}

机构：

[1] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Dept Biochem & Mol Biol,Inst Med Sci, Chunchon 200701, South Korea

[2] Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Dept Anat Pathol, Chunchon 200701, South Korea

[3] Kangwon Natl Univ, Coll Nat Sci, Dept Biol Sci, Chunchon 200701, South Korea

[4] Kangwon Natl Univ, Coll Biomed Sci, Inst Biosci & Biotechnol, Dept Med Biotechnol, Chunchon 200701, South Korea

[5] Kangwon Natl Univ, Sch Med, Dept Internal Med, Chunchon 200701, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2012年 / 44卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

caveolin-1; cyclooxygenase inhibitors; procollagen; skin aging; KAPPA-B-ALPHA; CELLULAR SENESCENCE; GENE-EXPRESSION; REPLICATIVE SENESCENCE; COLLAGEN; AGE; CAVEOLIN-1; CELLS; P53; PURIFICATION;

D O I：

10.3858/emm.2012.44.9.061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a causal factor for aging and whether COX-2 inhibitors could prevent aging. We here examined the effect of COX-2 inhibitors on aging in the intrinsic skin aging model of hairless mice. We observed that among two selective COX-2 inhibitors and one non-selective COX inhibitor studied, only NS-398 inhibited skin aging, while celecoxib and aspirin accelerated skin aging. In addition, NS-398 reduced the expression of p53 and p16, whereas celecoxib and aspirin enhanced their expression. We also found that the aging-modulating effect of the inhibitors is closely associated with the expression of type I procollagen and caveolin-1. These results suggest that pro-inflammatory catalytic activity of COX-2 is not a causal factor for aging at least in skin and that COX-2 inhibitors might modulate skin aging by regulating the expression of type I procollagen and caveolin-1.

引用

页码：536 / 544

页数：9

共 40 条

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