NF-KB inhibitors gifted by nature: The anticancer promise of polyphenol compounds

被引：44
作者：
Guan, Chengcheng [1 ]
Zhou, Xintong [2 ]
Li, Huayao [3 ]
Ma, Xiaoran [4 ]
Zhuang, Jing [5 ,6 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Clin Med 1, Jinan 250022, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan 250022, Peoples R China
[3] Weifang Med Univ, Coll Tradit Chinese Med, Weifang 261000, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Coll Clin Med 1, Jinan, Peoples R China
[5] Weifang Tradit Chinese Hosp, Dept Oncol, Weifang 261000, Peoples R China
[6] Weifang Tradit Chinese Hosp, Weifang, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 156卷
基金：
中国国家自然科学基金;
关键词：
Polyphenol compounds; Tumor; NF-KB; Antioxidant; Transcription factor; MEDIATED UP-REGULATION; CANCER CELL-MIGRATION; KAPPA-B ACTIVATION; LUNG-CANCER; PANCREATIC-CANCER; PROSTATE-CANCER; MESENCHYMAL TRANSITION; COLORECTAL-CANCER; IN-VITRO; CURCUMIN;
D O I：
10.1016/j.biopha.2022.113951
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Polyphenol compounds are natural antioxidants, which are rich in anti-inflammatory and antioxidant compo-nents. They have a wide range of medicinal benefits that are believed to improve human health across various aspects; especially its anticancer effect has been gradually confirmed. The anticancer effect of polyphenols is mainly based on their strong antioxidant and immunomodulatory effects. The innate and adaptive immune re-sponses as well as the development and maintenance of cells and tissues of the immune system are regulated by the NF -KB family of transcription factors. Dysregulation of NF -KB can lead to autoimmune diseases, chronic inflammation, and even cancer. Polyphenol compounds can exert antioxidant and immunomodulatory effects by targeting NF -KB, thus hindering the occurrence and development of tumors.Polyphenol compounds have unique advantages over conventional anticancer therapies such as chemotherapy because they have few side effects and do not cause toxicity to healthy cells. Additionally, they can attenuate the toxic effects of current anticancer therapies. Based on these characteristics, polyphenols have great potential in the prevention and treatment of cancer. This article systematically summarizes the mechanism of NF -KB in tumor genesis, progression, metastasis, angiogenesis, and drug resistance. In addition, we present the anticancer effect of polyphenol compounds by targeting NF -KB during the different stages of tumorigenesis.
引用
收藏
页数：13
相关论文
共 138 条
[11]   NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond [J].
Capece, Daria ;
Verzella, Daniela ;
Di Francesco, Barbara ;
Alesse, Edoardo ;
Franzoso, Guido ;
Zazzeroni, Francesca .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 98 :118-128
[12]   Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity [J].
Chao, Sung-Chuan ;
Chen, Ying-Ju ;
Huang, Kuo-How ;
Kuo, Kuan-Lin ;
Yang, Ting-Hua ;
Huang, Kuo-Yuan ;
Wang, Ching-Chia ;
Tang, Chih-Hsin ;
Yang, Rong-Sen ;
Liu, Shing-Hwa .
SCIENTIFIC REPORTS, 2017, 7
[13]   Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3/NF-kB/IL-6 and VEGF Loop [J].
Chen, Cheng ;
You, Fei ;
Wu, FengHua ;
Luo, YuShen ;
Zheng, GuoHua ;
Xu, HanLin ;
Liu, Yi .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020
[14]   Luteolin attenuates TGF-β1-induced epithelial-mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt-NF-κB-Snail pathway [J].
Chen, Kun-Chieh ;
Chen, Chiu-Yuan ;
Lin, Chih-Ju ;
Yang, Tsung-Ying ;
Chen, Tzu-Hsiu ;
Wu, Li-Chen ;
Wu, Chun-Chi .
LIFE SCIENCES, 2013, 93 (24) :924-933
[15]   NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target [J].
Chen, Wenshu ;
Li, Zi ;
Bai, Lang ;
Lin, Yong .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2011, 16 :1172-1185
[16]   Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells [J].
Coker-Gurkan, Ajda ;
Bulut, Derya ;
Genc, Recep ;
Arisan, Elif-Damla ;
Obakan-Yerlikaya, Pinar ;
Palavan-Unsal, Narcin .
MOLECULAR BIOLOGY REPORTS, 2019, 46 (01) :355-369
[17]   Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells [J].
Coker-Gurkan, Ajda ;
Celik, Merve ;
Ugur, Merve ;
Arisan, Elif-Damla ;
Obakan-Yerlikaya, Pinar ;
Durdu, Zeynep Begum ;
Palavan-Unsal, Narcin .
AMINO ACIDS, 2018, 50 (08) :1045-1069
[18]   Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis [J].
Conlon, Guy A. ;
Murray, Graeme I. .
JOURNAL OF PATHOLOGY, 2019, 247 (05) :629-640
[19]   Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor-Kappa B (NF-κB) Inhibitors [J].
Das, Rina ;
Mehta, Dinesh Kumar ;
Dhanawat, Meenakshi .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2022, 22 (15) :1938-1962
[20]   Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth [J].
De Simone, V. ;
Franze, E. ;
Ronchetti, G. ;
Colantoni, A. ;
Fantini, M. C. ;
Di Fusco, D. ;
Sica, G. S. ;
Sileri, P. ;
MacDonald, T. T. ;
Pallone, F. ;
Monteleone, G. ;
Stolfi, C. .
ONCOGENE, 2015, 34 (27) :3493-3503
12345678910