Serum magnesium level and hematoma expansion in patients with intracerebral hemorrhage

被引：28

作者：

Jafari, Mostafa ^{[1
]}

Di Napoli, Mario ^{[2
]}

Lattanzi, Simona ^{[3
]}

Mayer, Stephan A. ^{[4
]}

Bachour, Salam ^{[5
]}

Bershad, Eric M. ^{[6
]}

Damani, Rahul ^{[6
]}

Datta, Yvonne H. ^{[7
]}

Divani, Afshin A. ^{[1
,8
]}

机构：

[1] Univ Minnesota, Dept Neurol, MMC 295,420 Delaware St SE, Minneapolis, MN 55455 USA

[2] San Camillo de Lellis Dist Gen Hosp, Dept Neurol, Rieti, Italy

[3] Marche Polytech Univ, Neurol Clin, Dept Expt & Clin Med, Ancona, Italy

[4] Henry Ford Hlth Syst, Dept Neurol, Detroit, MI USA

[5] Cleveland Clin, Lerner Coll Med, Cleveland, OH 44106 USA

[6] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[7] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Box 736 UMHC, Minneapolis, MN 55455 USA

[8] Univ Minnesota, Dept Neurosurg, Minneapolis, MN 55455 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2019年 / 398卷

关键词：

Intracerebral hemorrhage; Serum magnesium; Hematoma expansion; Clinical outcome; INFLAMMATORY RESPONSE; CEREBRAL-HEMORRHAGE; ISCHEMIC-STROKE; IONIZED MAGNESIUM; PLATELET; HYPERTENSION; COAGULATION; VOLUME; MG2+; PREDICTOR;

D O I：

10.1016/j.jns.2019.01.027

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Spontaneous intracerebral hemorrhage (ICH) is a devastating subtype of stroke that results in significant rates of mortality and morbidities. The initial hematoma volume, hematoma expansion (HE), blood pressure (BP), and coagulopathy are considered strong predictors of clinical outcomes and mortality. Low serum magnesium (Mg++) levels have been shown to be associated with larger initial hematoma and greater HE. Coagulopathy, platelet dysfunction, high BP, and increased inflammatory response might form the mechanistic link between low serum Mg++ levels, larger hematoma size and greater HE. However, randomized clinical trials administering intravenous Mg++ have shown no benefit over placebo in ICH patients. The confounding effect of hypocalcemia and a delay in Mg++ trafficking across the blood-brain barrier might explain the futile results for intravenous Mg++ therapy. In the current review, we will discuss the evidence regarding the possible role of low serum Mg' level on HE in acute ICH.

引用

页码：39 / 44

页数：6