Green tea for ovarian cancer prevention and treatment: A systematic review of the in vitro, in vivo and epidemiological studies

被引：35

作者：

Trudel, Dominique ^{[1
,2
]}

Labbe, David P. ^{[3
,4
]}

Bairati, Isabelle ^{[2
]}

Fradet, Vincent ^{[2
,5
]}

Bazinet, Laurent ^{[5
]}

Tetu, Bernard ^{[2
,6
]}

机构：

[1] Toronto Gen Hosp, Univ Hlth Network, Dept Pathol Appl Mol Oncol, Toronto, ON M5G 2C4, Canada

[2] Univ Laval, Canc Res Ctr, Hotel Dieu de Quebec, Univ Hosp Ctr CHUQ, Quebec City, PQ G1R 2J6, Canada

[3] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada

[4] McGill Univ, Div Expt Med, Dept Med, Montreal, PQ H3A 1A3, Canada

[5] Univ Laval, Dept Food Sci & Nutr, Inst Nutraceut & Funct Foods INAF, Quebec City, PQ G1V 0A6, Canada

[6] Univ Laval, Anat Pathol & Cytol Dept, Hop St Sacrement, CHA, Quebec City, PQ G1S 4L8, Canada

来源：

GYNECOLOGIC ONCOLOGY | 2012年 / 126卷 / 03期

关键词：

Epithelial ovarian cancer; Green tea; Camellia sinensis; Epigallocatechin gallate (EGCG); Human; Meta-analysis; CELL-LINES; BLACK TEA; POLYPHENOL EPIGALLOCATECHIN-3-GALLATE; GLUTAMATE TRANSPORTER; PROSPECTIVE COHORT; ANTITUMOR-ACTIVITY; FLAVONOID INTAKE; COFFEE-DRINKING; ENDOTHELIN AXIS; PHASE-I;

D O I：

10.1016/j.ygyno.2012.04.048

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. This systematic review was conducted to examine the effects of green tea or green tea components on the prevention and progression of epithelial ovarian cancer. Methods. Using Medline, EMBASE and SciVerse (last researched: July 2011), we retrieved 22 articles including 5 epidemiological studies. Results. In epithelial ovarian cancer cell lines, green tea and green tea components have been shown to downregulate the expression of proteins involved in inflammation, cell signalization, cell motility and angiogenesis. Green tea and green tea components would induce apoptosis and could potentiate the effects of cisplatin, a chemotherapeutic agent. In human observational studies, significant associations between green tea intake and both decreased ovarian cancer occurrence and better prognosis were reported. Conclusions. Available literature suggests potential molecular targets for green tea in ovarian cancer treatment and also provides data supporting the clinical evaluation of the role of green tea or green tea components in ovarian cancer prevention and treatment. (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：491 / 498

页数：8

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