Otic placode cell specification and proliferation are regulated by Notch signaling in avian development

被引:5
|
作者
Shida, Hiroko [1 ,2 ]
Mende, Michael [3 ]
Takano-Yamamoto, Teruko [2 ]
Osumi, Noriko [1 ]
Streit, Andrea [3 ]
Wakamatsu, Yoshio [1 ]
机构
[1] Tohoku Univ, Dept Dev Neurosci, Grad Sch Med, Ctr Translat & Adv Anim Res, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Div Orthodont & Dentofacial Orthoped, Grad Sch Dent, Sendai, Miyagi 9808575, Japan
[3] Kings Coll London, Dept Craniofacial Dev & Stem Cell Biol, London WC2R 2LS, England
基金
英国生物技术与生命科学研究理事会;
关键词
otic placode; Notch; Delta; Hes; Pax2; Sox9; CHICK INNER-EAR; LATERAL INHIBITION; PROSENSORY PATCHES; FATE DETERMINATION; EXPRESSION; WNT; INDUCTION; SOX9; PATHWAY; DELTA;
D O I
10.1002/dvdy.24291
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Background: The entire inner ear including the cochlear-vestibular ganglion arises from a simple epithelium, the otic placode. Precursors for the placode originate from a pool of progenitors located in ectoderm next to the future hindbrain, the pre-otic field, where they are intermingled with future epibranchial and epidermal cells. While the importance of secreted proteins, such as FGFs and Wnts, in imparting otic identity has been well studied, how precursors for these different fates segregate locally is less well understood. Results: (1) The Notch ligand Delta1 and the Notch target Hes5-2 are expressed in a part of pre-otic field before otic commitment, indicative of active Notch signaling, and this is confirmed using a Notch reporter. (2) Loss and gain-of-function approaches reveal that Notch signaling regulates both proliferation and specification of pre-otic progenitors. Conclusions: Our results identify a novel function of Notch signaling in cell fate determination in the pre-otic field of avian embryos. Developmental Dynamics 244: 839-851, 2015. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:839 / 851
页数:13
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