Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer

被引：28

作者：

Avincsal, Mehmet Ozgur ^{[1
,2
]}

Shinomiya, Hirotaka ^{[1
]}

Teshima, Masanori ^{[1
]}

Kubo, Mie ^{[1
]}

Otsuki, Naoki ^{[1
]}

Kyota, Naomi ^{[4
]}

Sasaki, Ryohei ^{[3
]}

Zen, Yoh ^{[2
]}

Nibu, Ken-ichi ^{[1
]}

机构：

[1] Kobe Univ, Dept Otolaryngol Head & Neck Surg, Grad Sch Med, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Dept Diagnost Pathol, Grad Sch Med, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan

[3] Kobe Univ, Dept Radiat Oncol, Grad Sch Med, Kobe, Hyogo, Japan

[4] Kobe Univ, Dept Med Oncol & Hematol, Grad Sch Med, Kobe, Hyogo, Japan

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2018年 / 40卷 / 04期

关键词：

alcohol dehydrogenase-aldehyde dehydrogenase (ADH-ALDH) polymorphism; head and neck cancers; hypopharyngeal cancers; prognosis; SQUAMOUS-CELL CARCINOMA; NECK-CANCER; HEAD; RISK; ESOPHAGEAL; JAPANESE; DRINKING; SMOKING; LESIONS;

D O I：

10.1002/hed.25050

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

BackgroundThe purpose of this research was to investigate the association between alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) polymorphisms and hypopharyngeal squamous cell carcinoma (SCC) survival. MethodsWe genotyped ADH1B (rs1229984) and ALDH2 (rs671) single nucleotide polymorphisms (SNPs) in 85 Japanese male patients with hypopharyngeal SCC. The independent prognostic values of ADH1B-ALDH2 genotypes were analyzed by univariate and multivariate proportional hazard Cox regression, taking well-known clinical risk factors into account. ResultsHeavy drinkers with ALDH2*2 allele resulted in significantly worse overall survival (OS; P = .028) and disease-free survival (DFS; P = .029) compared with other patients. Heavy drinkers with ALDH2*2 allele remained statistically significant in multivariate analysis for OS and DFS, indicating independent poor prognostic factor (hazard ratio [HR] 2.251; 95% confidence interval [CI] 1.018-4.975 and HR 2.261; 95% CI 1.021-5.006, respectively). ConclusionWe conclude that heavy drinkers with the ALDH2*2 allele are associated with poor outcome in hypopharyngeal SCC.

引用

页码：770 / 777

页数：8

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