Anti-Inflammatory Polyoxygenated Steroids from the Soft Coral Lobophytum michaelae

被引：26

作者：

Huang, Chiung-Yao ^{[1
]}

Tseng, Wan-Ru ^{[1
]}

Ahmed, Atallah E. ^{[2
]}

Chiang, Pei-Lun ^{[3
]}

Tai, Chi-Jen ^{[4
,5
]}

Hwang, Tsong-Long ^{[6
,7
,8
,9
]}

Dai, Chang-Feng ^{[10
]}

Sheu, Jyh-Horng ^{[1
,11
,12
,13
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia

[3] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada

[4] Natl Sun Yat Sen Univ, Program Marine Biotechnol, Kaohsiung 804, Taiwan

[5] Acad Sinica, Kaohsiung 804, Taiwan

[6] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Taoyuan 333, Taiwan

[7] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med, Taoyuan 333, Taiwan

[8] Chang Gung Univ Sci & Technol, Coll Human Ecol, Grad Inst Hlth Ind Technol, Taoyuan 333, Taiwan

[9] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan 333, Taiwan

[10] Natl Taiwan Univ, Inst Oceanog, Taipei 112, Taiwan

[11] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[12] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan

[13] Natl Sun Yat Sen Univ, Frontier Ctr Ocean Sci & Technol, Kaohsiung 804, Taiwan

来源：

MARINE DRUGS | 2018年 / 16卷 / 03期

关键词：

soft coral; Lobophytum michaelae; cytotoxicity; anti-inflammatory activity; INHIBITS SUPEROXIDE-PRODUCTION; CYTOTOXIC CEMBRANOLIDES; HUMAN NEUTROPHILS; CRASSUM; STEREOISOMERS; DITERPENOIDS;

D O I：

10.3390/md16030093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and comparison of the nuclear magnetic resonance (NMR) data with related steroids. The cytotoxicity of compounds 1-3 against the proliferation of a limited panel of cancer cell lines was assayed. Compound 1 was found to display moderate cytotoxicity against adenocarcinomic human alveolar basal epithelial (A549) cancer cells. It also exhibited potent anti-inflammatory activity by suppressing superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-stimulated human neutrophils. Furthermore, 3 could effectively inhibit elastase release, as well.

引用

页数：10

共 28 条

[1] Anti-Inflammatory Lobane and Prenyleudesmane Diterpenoids from the Soft Coral Lobophytum varium [J].