The XRCC1 Arg399Gln Gene Polymorphism and Risk of Colorectal Cancer: a Study in Kashmir

被引：9
作者：
Khan, Nighat Parveen
Pandith, Arshad Ahmad
Yousuf, Adfar
Khan, Nuzhat Shaheen [1 ]
Khan, Mosin Saleem
Bhat, Imtiyaz Ahmad
Nazir, Zahoor Wani
Wani, Khursheed Alam
Hussain, Mahboob Ul [2 ]
Mudassar, Syed
机构：
[1] Univ Kashmir, Dept Biochem, Kashmir, India
[2] Univ Kashmir, Dept Biotechnol, Kashmir, India
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2013年 / 14卷 / 11期
关键词：
X-ray cross complementing gene; SNP; DNA Repair; colorectal cancer; Kahsmiri population; BASE EXCISION-REPAIR; DNA-POLYMERASE BETA; POLY(ADP-RIBOSE) POLYMERASE; GASTRIC-CANCER; XPD; SUSCEPTIBILITY; CARCINOMA;
D O I：
10.7314/APJCP.2013.14.11.6779
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The DNA repair gene XRCC1 Arg399Gln gene polymorphism has been found to be implicated in the development of various cancers, including colorectal cancer (CRC), in different populations. We aimed to determine any association of this polymorphism with the risk of CRC in Kashmir. Materials and Methods: included in this study. Genotyping was carried out by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Genotype frequencies of XRCC1 Arg399Gln observed in controls were 34.2%, 42.5% and 23.3% for GG (Arg/Arg), GA (Arg/Gln), AA(Gln/Gln), respectively, and 28.3%, 66.7% association of Arg399Gln SNP with any clinicopathological parameters of CRC was found. Conclusions: We found the protective role of 399Gln allele against risk to the development of CRC. The XRCC1 heterozygote status appears to be a strong risk factor for CRC development in the Kashmiri population.
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页码：6779 / 6782
页数：4
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