Endothelial Nitric Oxide Synthase Gene Polymorphisms and Risk of Preeclampsia

被引:20
作者
Qi, Hui-Ping [1 ]
Fraser, William D. [2 ]
Luo, Zhong-Cheng [2 ]
Julien, Pierre [3 ]
Audibert, Francois [2 ]
Wei, Shu-Qin [2 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Harbin, Peoples R China
[2] Univ Montreal, St Justine Hosp, Dept Obstet & Gynecol, Montreal, PQ H3S 2C3, Canada
[3] Univ Laval, CHUL Res Ctr CHUQ, Lab Endocrinol & Genom, Quebec City, PQ, Canada
关键词
preeclampsia; endothelial nitric oxide synthase; polymorphism; GLU298ASP VARIANT; L-ARGININE; VASOACTIVE GENES; NO ASSOCIATION; BLOOD-PRESSURE; PREGNANCY; ENOS; HYPERTENSION; METAANALYSIS; POPULATION;
D O I
10.1055/s-0032-1333406
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Polymorphisms in endothelial nitric oxide synthase (eNOS) gene may affect the risk of preeclampsia. This systematic review aimed to provide an updated review of the literature to better understand the association between the eNOS gene polymorphisms and the risk of preeclampsia. We searched electronic databases of the human literature in PubMed, EMBASE, and the Cochrane Library up to July 2012. A meta-analysis was conducted on the association of eNOS G894T, T786C, and intron 4b/a polymorphisms with preeclampsia using (1) allele contrast, (2) recessive, (3) dominant, and (4) additive models. Thirty-three studies comprising 10,671 participants met the inclusion criteria. There was statistically significant association between the G894T variant and increased risk of preeclampsia (TT versus TG + GG: odds ratio 1.43, 95% confidence interval: 1.13 to 1.82). However, no significant risk of preeclampsia was observed either in the T786C or the intron 4b/a polymorphism. Homozygosity TT in eNOS G894T variant is significantly associated with an increased risk of preeclampsia.
引用
收藏
页码:795 / 804
页数:10
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