Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi

被引：27

作者：

Huang, Hui-Chi

Tsai, Wei-Jern

Morris-Natschke, Susan L.

Tokuda, Harukuni

Lee, Kuo-Hsiung

Wu, Yang-Chang ^{[1
]}

Kuo, Yao-Haur

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Grad Inst Pharmaceut Sci, Kaohsiung 807, Taiwan

[3] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[4] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[5] Natl Taitung Univ, Inst Life Sci, Taitung 950, Taiwan

[6] Kyoto Prefectural Univ Med, Dept Biochem & Mol Biol, Kamigyo Ku, Kyoto 6020841, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 05期

关键词：

D O I：

10.1021/np050446z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new tirucallane-type saponins, sapinmusaponins F-J ( 1-5), were isolated from the galls of Sapindus mukorossi. The structures of these saponins were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques ( H-1-H-1 COSY, HMQC, HMBC, TOCSY, and NOESY). Compounds 1-5 showed anti-platelet-aggregation effects, but no obvious cytotoxic activity for platelets as assayed by lactate dehydrogenase ( LDH) leakage. Compounds 1-5 also showed moderate activity in a 12-O-tetradecanoylphorbol-13-acetate ( TPA)-induced Epstein-Barr virus early antigen ( EBV-EA) activation assay.

引用

页码：763 / 767

页数：5

共 29 条

[1] Gall-inducing insects provide insights into plant systematic relationships [J].