Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi

被引：27
|
作者：
Huang, Hui-Chi
Tsai, Wei-Jern
Morris-Natschke, Susan L.
Tokuda, Harukuni
Lee, Kuo-Hsiung
Wu, Yang-Chang [1 ]
Kuo, Yao-Haur
机构：
[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Grad Inst Pharmaceut Sci, Kaohsiung 807, Taiwan
[3] Natl Res Inst Chinese Med, Taipei 112, Taiwan
[4] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA
[5] Natl Taitung Univ, Inst Life Sci, Taitung 950, Taiwan
[6] Kyoto Prefectural Univ Med, Dept Biochem & Mol Biol, Kamigyo Ku, Kyoto 6020841, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 05期
关键词：
D O I：
10.1021/np050446z
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new tirucallane-type saponins, sapinmusaponins F-J ( 1-5), were isolated from the galls of Sapindus mukorossi. The structures of these saponins were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques ( H-1-H-1 COSY, HMQC, HMBC, TOCSY, and NOESY). Compounds 1-5 showed anti-platelet-aggregation effects, but no obvious cytotoxic activity for platelets as assayed by lactate dehydrogenase ( LDH) leakage. Compounds 1-5 also showed moderate activity in a 12-O-tetradecanoylphorbol-13-acetate ( TPA)-induced Epstein-Barr virus early antigen ( EBV-EA) activation assay.
引用
收藏
页码：763 / 767
页数：5
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