Fibroblast growth factor signaling in embryonic and cancer stem cells

被引：83
作者：
Dvorak, Petr
Dvorakova, Dana
Hampl, Ales
机构：
[1] Masaryk Univ, Fac Med, Dept Biol, Brno 62500, Czech Republic
[2] Univ Hosp Brno, Dept Internal Med Hemaooncol, Brno, Czech Republic
[3] Acad Sci Czech Republ, Inst Expt Med, Dept Mol Embryol, Prague, Czech Republic
[4] Charles Univ Prague, Fac Med 2, Ctr Cell Therapy & Tissue Repair, Prague, Czech Republic
来源：
FEBS LETTERS | 2006年 / 580卷 / 12期
关键词：
fibroblast growth factor 2; signaling; embryonic stem cell; hematopoietic progenitor cell; cancer;
D O I：
10.1016/j.febslet.2006.01.095
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer stem cells are cancer cells that originate from the transformation of normal stem cells. The most important property of any stem cell is the ability to self-renew. Through this property, there are striking parallels between normal stem cells and cancer stem cells. Both cell types share various markers of "stemness". In particular, normal stem cells and cancer stem cells utilize similar molecular mechanisms to drive self-renewal, and similar signaling pathways may induce their differentiation. The fibroblast growth factor 2 (FGF-2) pathway is one of the most significant regulators of human embryonic stem cell (hESC) self-renewal and cancer cell tumorigenesis. Here we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also, we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：2869 / 2874
页数：6
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