Taurine Protects Mouse Liver Against Arsenic-Induced Apoptosis Through JNK Pathway

被引：13

作者：

Li, Shuangxing ^{[1
]}

Yang, Lijun ^{[2
]}

Dong, Guangtao ^{[1
]}

Wang, Xiujie ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Emergency Surg, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China

[2] Dalian Ctr Dis Control & Prevent, Dalian, Peoples R China

来源：

TAURINE 10 | 2017年 / 975卷

基金：

中国国家自然科学基金;

关键词：

Taurine; Arsenic; Apoptosis; JNK signaling; Liver; TRANSPORTER KNOCKOUT; OXIDATIVE STRESS; RAT; HEPATOTOXICITY; MECHANISM; TOXICITY; ISCHEMIA; NEURONS; MICE;

D O I：

10.1007/978-94-024-1079-2_67

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A great number of evidences demonstrated that the increased apoptosis is related to arsenic (As)-induced liver injury. The object of the present study was to explore the protection of taurine (Tau) against As-induced impairment in liver and the related mechanism. Adult mice were divided into control group, As exposure group and Tau protection group. The results of RT-PCR and WB showed that Tau treatment significantly reversed the disturbance of Bax and Bcl-2 expression. The release of cytochrome c and caspase-3 activation in liver both were prohibited by Tau in As-intoxicated mice. Furthermore, Tau markedly attenuated As-induced decrease of p-JNK level in mouse liver. These results indicated that Tau attenuated As-induced hepatic injury via JNK pathway.

引用

页码：855 / 862

页数：8

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