CANCER Physical traits of cancer

被引：459
作者：
Nia, Hadi T. [1 ,2 ,3 ]
Munn, Lance L. [1 ,2 ]
Jain, Rakesh K. [1 ,2 ,4 ]
机构：
[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Steele Labs, Boston, MA 02114 USA
[2] Harvard Med Sch, Boston, MA 02114 USA
[3] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[4] Harvard Med Sch, Ludwig Ctr, Harvard, Boston, MA 02115 USA
来源：
SCIENCE | 2020年 / 370卷 / 6516期
关键词：
INTERSTITIAL FLUID PRESSURE; BETA-CATENIN ACTIVATION; SHEAR-WAVE ELASTOGRAPHY; TUMOR-CELL MIGRATION; MATRIX STIFFNESS; SOLID STRESS; NUCLEAR-ENVELOPE; BLOOD-VESSELS; MECHANICAL FORCES; TISSUE STIFFNESS;
D O I：
10.1126/science.aaz0868
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The role of the physical microenvironment in tumor development, progression, metastasis, and treatment is gaining appreciation. The emerging multidisciplinary field of the physical sciences of cancer is now embraced by engineers, physicists, cell biologists, developmental biologists, tumor biologists, and oncologists attempting to understand how physical parameters and processes affect cancer progression and treatment. Discoveries in this field are starting to be translated into new therapeutic strategies for cancer. In this Review, we propose four physical traits of tumors that contribute to tumor progression and treatment resistance: (i) elevated solid stresses (compression and tension), (ii) elevated interstitial fluid pressure, (iii) altered material properties (for example, increased tissue stiffness, which historically has been used to detect cancer by palpation), and (iv) altered physical microarchitecture. After defining these physical traits, we discuss their causes, consequences, and how they complement the biological hallmarks of cancer.
引用
收藏
页码：546 / +
页数：10
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