An in-Depth Analysis of the Swelling, Mechanical, Electrical, and Drug Release Properties of Agar-Gelatin Co-Hydrogels

被引：4

作者：

Pandey, Preeti Madhuri ^{[1
]}

Nayak, Suraj K. ^{[1
]}

Shaw, Gauri Shankar ^{[1
]}

Uvanesh, K. ^{[1
]}

Banerjee, I. ^{[1
]}

Al-Zahrani, S. M. ^{[2
]}

Anis, Arfat ^{[2
]}

Pal, Kunal ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Biotechnol & Med Engn, Rourkela 769008, India

[2] King Saud Univ, Dept Chem Engn, Riyadh 11421, Saudi Arabia

来源：

POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2017年 / 56卷 / 06期

关键词：

Agar; co-hydrogels; drug release; gelatin; impedance spectroscopy; viscoelasticity; STRESS-RELAXATION; SKIN GELATIN; BEHAVIOR; KINETICS; DELIVERY; CHITOSAN;

D O I：

10.1080/03602559.2016.1211694

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Agar-gelatin-based co-hydrogels were prepared with different compositions of the agar and the gelatin fractions. The intermolecular hydrogen bonding was higher in the co-hydrogels as compared to the gelatin hydrogel. Swelling studies indicated diffusion-mediated swelling. The electrical stability of the co-hydrogels was higher as compared to the gelatin hydrogel. Though the firmness of the co-hydrogels was higher, Weichert model of viscoelasticity indicated that the inherent mechanical stability of the gelatin hydrogel was superior. The release of ciprofloxacin hydrochloride was predominately Fickian diffusion-mediated. In gist, the co-hydrogels can be tried as polymeric constructs for controlled drug delivery applications. [GRAPHICS] .

引用

页码：667 / 677

页数：11

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