New Amide Derivatives as Melanin-concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity

被引：0
|
作者：
Cirauqui, Nuria [1 ]
Ceras, Javier [1 ]
Galiano, Silvia [1 ]
Perez-Silanes, Silvia [1 ]
Juanenea, Laura [1 ]
Rivera, Gildardo [1 ]
Aldana, Ignacio [1 ]
Monge, Antonio [1 ]
机构：
[1] Univ Navarra, CIFA, Unidad Invest & Desarrollo Medicamentos, E-31080 Pamplona, Spain
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2008年 / 58卷 / 11期
关键词：
Melanin-concentrating hormone; amide derivatives; biphenylamide; diphenylamide; Melanin-concentrating hormone receptor 1; antagonists; Obesity;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Melanin-concentrating hormone (MCH) is a recently discovered central nervous system (CNS) target for treating obesity. Two novel series of amide derivatives were synthesized and evaluated biologically as MCH-R1 (melanin-concentrating hormone receptor 1) antagonists. The results showed that diphenyl substituents on the amide lead to better activity than biphenyl substituents.
引用
收藏
页码：585 / 591
页数：7
相关论文
共 50 条
  • [1] Melanin-concentrating hormone receptor 1 antagonists:: A new perspective for the pharmacologic treatment of obesity
    Rivera, Gildardo
    Bocanegra-Garcia, Virgilio
    Galiano, Silvia
    Cirauqui, Nuria
    Ceras, Javier
    Perez, Silvia
    Aldana, Ignacio
    Monge, Antonio
    CURRENT MEDICINAL CHEMISTRY, 2008, 15 (10) : 1025 - 1043
  • [2] Discovery and development of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity
    Rokosz, Laura L.
    EXPERT OPINION ON DRUG DISCOVERY, 2007, 2 (10) : 1301 - 1327
  • [3] Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for obesity the treatment of obesity
    Kowalski, TJ
    McBriar, MD
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2004, 13 (09) : 1113 - 1122
  • [4] Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity
    Mihalic, Jeffrey T.
    Chen, Xiaoqi
    Fan, Pingchen
    Chen, Xi
    Fu, Ying
    Liang, Lingming
    Reed, Michael
    Tang, Liang
    Chen, Jin-Long
    Jaen, Juan
    Li, Leping
    Dai, Kang
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (23) : 7001 - 7005
  • [5] Melanin-concentrating hormone receptor 1 antagonists for the treatment of depression and anxiety
    Chaki, S
    Yamaguchi, JI
    Yamada, H
    Kanuma, K
    Sekiguchi, Y
    DRUG DEVELOPMENT RESEARCH, 2005, 65 (04) : 278 - 290
  • [6] Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists
    Ando, Makoto
    Sekino, Etsuko
    Haga, Yuji
    Moriya, Minoru
    Ito, Masahiko
    Ito, Junko
    Iwaasa, Hisashi
    Ishihara, Akane
    Kanatani, Akio
    Ohtake, Norikazu
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (17) : 5186 - 5190
  • [7] Recent advances in the discovery of melanin-concentrating hormone receptor antagonists
    McBriar, Mark D.
    CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2006, 9 (04) : 496 - 508
  • [8] Recent progress in the discovery of melanin-concentrating hormone 1-receptor antagonists
    Johansson, Anders
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2011, 21 (06) : 905 - 925
  • [9] Anti-obesity effects of small molecule melanin-concentrating hormone receptor1 (MCHR1) antagonists
    Luthin, David R.
    LIFE SCIENCES, 2007, 81 (06) : 423 - 440
  • [10] Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity
    Souers, AJ
    Gao, J
    Wodka, D
    Judd, AS
    Mulhern, MM
    Napier, JJ
    Brune, ME
    Bush, EN
    Brodjian, SJ
    Dayton, BD
    Shapiro, R
    Hernandez, LE
    Marsh, KC
    Sham, HL
    Collins, CA
    Kym, PR
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (11) : 2752 - 2757
12345