First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease

被引：8

作者：

George, M. Patricia ^{[1
,2
,3
,4
]}

Novelli, Enrico M. ^{[1
,2
,3
,4
]}

Shigemura, Norihisa ^{[1
,2
,3
,4
]}

Simon, Marc A. ^{[1
,2
,3
,4
]}

Feingold, Brian ^{[1
,2
,3
,4
,5
]}

Krishnamurti, Lakshmanan ^{[1
,2
,3
,4
,5
]}

Morrell, Matthew R. ^{[1
,2
,3
,4
]}

Gries, Cynthia G. ^{[1
,2
,3
,4
]}

Haider, Syed ^{[1
,2
,3
,4
]}

Johnson, Bruce A. ^{[1
,2
,3
,4
]}

Crespo, Maria M. ^{[1
,2
,3
,4
]}

Bhama, Jay K. ^{[1
,2
,3
,4
]}

Bermudez, Christian ^{[1
,2
,3
,4
]}

Yousem, Samuel A. ^{[1
,2
,3
,4
]}

Toyoda, Yoshiya ^{[6
]}

Champion, Hunter C. ^{[1
,2
,3
,4
]}

Pilewski, Joseph M. ^{[1
,2
,3
,4
]}

Gladwin, Mark T. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Dept Pediat, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA

[4] Univ Pittsburgh, Sch Med, Dept Surg, Pittsburgh, PA USA

[5] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

[6] Temple Univ, Sch Med, Philadelphia, PA 19122 USA

来源：

PULMONARY CIRCULATION | 2013年 / 3卷 / 04期

关键词：

lung transplantation; sickle cell disease; pulmonary arterial hypertension; pulmonary veno-occlusive disease;

D O I：

10.1086/674749

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Little is known about the use of lung transplantation in the management of sickle cell disease-associated pulmonary arterial hypertension (SCD-PAH). We present clinical and pathological data and report the first successful outcome of bilateral lung transplantation in a patient with severe SCD-PAH and pulmonary veno-occlusive disease (PVOD). We discuss the complexities of multidisciplinary planning and management of lung transplantation in patients with SCD-associated pulmonary vascular complications. This case reports the first documented successful lung transplant and first case of PVOD in a patient with SCD-PAH.

引用

页码：952 / 958

页数：7

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