Scrotal scintigraphy has no proved value in the diagnosis of testicular tumors. If performed, the appearance on dynamic and static images can vary, reflecting the relative vascularity and blood pool of the tumor mass. Sometimes, in a patient with acute testicular symptoms, the clinical picture and scintigraphic findings of increased perfusion and blood pool activity in a hypervascular testicular neoplasm can be mistaken for epididymo-orchitis, leading to a delay in diagnosis and treatment. The authors describe a patient with testicular seminoma whose clinical presentation and scrotal scintigraphic findings were compatible with epididymo-orchitis. This case highlights a potential pitfall of scrotal scintigraphy in differentiating a hypervascular testicular tumor from epididymo-orchitis.