Inhibitory Effect of Relaxin-3 on Insulin Secretion in Isolated Pancreas and Insulinoma

被引：2
作者：
Yamamoto, Hiroyuki [1 ]
Arai, Takeo [1 ]
Tasaka, Ryota [1 ]
Mori, Yasunori [1 ]
Iguchi, Kazuaki [1 ]
Unno, Keiko [1 ]
Hoshino, Minoru [1 ]
机构：
[1] Univ Shizuoka, Sch Pharmaceut Sci, Bioorgan Chem Lab, Shizuoka 4228526, Japan
来源：
JOURNAL OF HEALTH SCIENCE | 2009年 / 55卷 / 01期
关键词：
relaxin-3; G-protein-coupled receptor (GPCR)135; insulin; RECEPTORS; IDENTIFICATION; EXPRESSION; LIGAND; SOMATOSTATIN; MECHANISM; GENE; LGR7;
D O I：
10.1248/jhs.55.132
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Relaxin-3 is a recently discovered member of the insulin superfamily and is a ligand for three orphan G-protein-coupled receptors: GPCR135, GPCR142 and LGR7 (leucine-rich repeat-containing G-protein-coupled receptor 7). GPCR135 mRNA is expressed in the pancreas, however, it is not known, whether the peptide affects pancreatic islet function. Reverse transcriptase (RT)-PCR and radioreceptor assay have shown that the relaxin-3 receptor (GPCR135) is expressed in pancreatic islets and rat insulinoma, but LGR7 is not expressed. Moreover, relaxin-3 has been revealed to inhibit the secretion of insulin from pancreatic islets. However, we can not detect relaxin-3 in small intestine and pancreas. These results suggest a novel role of relaxin-3 in the regulation of insulin release.
引用
收藏
页码：132 / 137
页数：6
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