Inhibitory Effect of Relaxin-3 on Insulin Secretion in Isolated Pancreas and Insulinoma

被引：2

作者：

Yamamoto, Hiroyuki ^{[1
]}

Arai, Takeo ^{[1
]}

Tasaka, Ryota ^{[1
]}

Mori, Yasunori ^{[1
]}

Iguchi, Kazuaki ^{[1
]}

Unno, Keiko ^{[1
]}

Hoshino, Minoru ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Pharmaceut Sci, Bioorgan Chem Lab, Shizuoka 4228526, Japan

来源：

JOURNAL OF HEALTH SCIENCE | 2009年 / 55卷 / 01期

关键词：

relaxin-3; G-protein-coupled receptor (GPCR)135; insulin; RECEPTORS; IDENTIFICATION; EXPRESSION; LIGAND; SOMATOSTATIN; MECHANISM; GENE; LGR7;

D O I：

10.1248/jhs.55.132

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Relaxin-3 is a recently discovered member of the insulin superfamily and is a ligand for three orphan G-protein-coupled receptors: GPCR135, GPCR142 and LGR7 (leucine-rich repeat-containing G-protein-coupled receptor 7). GPCR135 mRNA is expressed in the pancreas, however, it is not known, whether the peptide affects pancreatic islet function. Reverse transcriptase (RT)-PCR and radioreceptor assay have shown that the relaxin-3 receptor (GPCR135) is expressed in pancreatic islets and rat insulinoma, but LGR7 is not expressed. Moreover, relaxin-3 has been revealed to inhibit the secretion of insulin from pancreatic islets. However, we can not detect relaxin-3 in small intestine and pancreas. These results suggest a novel role of relaxin-3 in the regulation of insulin release.

引用

页码：132 / 137

页数：6

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