Object-oriented Bayesian networks for paternity cases with allelic dependencies

被引:13
|
作者
Hepler, Amanda B. [1 ]
Weir, Bruce S. [2 ]
机构
[1] UCL, Dept Stat Sci, London WC1E 6BT, England
[2] Univ Washington, Dept Biostat, Seattle, WA 98195 USA
关键词
DNA evidence; Probabilistic expert systems; Evidence interpretation; Paternity index; Avuncular index;
D O I
10.1016/j.fsigen.2007.12.003
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
This study extends the current use of Bayesian networks by incorporating the effects of allelic dependencies in paternity calculations. The use of object-oriented networks greatly simplify the process of building and interpreting forensic identification models, allowing researchers to solve new, more complex problems. We explore two paternity examples: the most common scenario where DNA evidence is available from the alleged father, the mother and the child; a more complex case where DNA is not available from the alleged father, but is available from the alleged father's brother. Object-oriented networks are built, using HUGIN, for each example which incorporate the effects of allelic dependence caused by evolutionary relatedness. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:166 / 175
页数:10
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