LncRNA PITPNA-AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA

被引：43
|
作者：
Ren, Ping [1 ]
Xing, Lei [1 ]
Hong, Xiaodong [1 ]
Chang, Liang [1 ]
Zhang, Hong [1 ]
机构：
[1] First Hosp Jilin Univ, Dept Thorac Surg, Changchun 130021, Jilin, Peoples R China
来源：
CANCER MEDICINE | 2020年 / 9卷 / 20期
关键词：
HMGB3; lung squamous cell carcinoma (LUSC); PITPNA antisense RNA 1 (PITPA-AS1); TAF15; HEPATOCELLULAR-CARCINOMA; BINDING PROTEINS; PROMOTES; METASTASIS;
D O I：
10.1002/cam4.3268
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Plenty of reports have probed the involvement of abnormally expressed lncRNAs in multiple cancers, including lung squamous cell carcinoma (LUSC). Through online database GEPIA, lncRNA PITPNA antisense RNA 1 (PITPNA-AS1) was highly expressed in LUSC samples, and these tendency was further affirmed in LUSC cells. The aim of current study was to investigate the related mechanism of PITPNA-AS1 in LUSC. Functional experiments verified that depletion of PITPNA-AS1 hampered the proliferative and migratory abilities, but accelerated apoptosis of LUSC cells. Additionally, we observed the increased expression of HMGB3 and its positive correlation with PITPNA-AS1 in LUSC samples. Interestingly, PITPNA-AS1 mainly located in the cytosol of LUSC cells, and also affected mRNA stability of HMGB3. Furthermore, the repressed mRNA stability of HMGB3 by PITPNA-AS1 via TAF15 was exposed through mechanism experiments. The mediatory function of PITPNA-AS1 on HMGB3 was validated via rescue assays. All in all, PITPNA-AS1 promoted the proliferation and migration of LUSC cells via stabilizing HMGB3 by TAF15. In conclusion, our study displayed a novel mechanism underlying PITPNA-AS1 in LUSC cells.
引用
收藏
页码：7706 / 7716
页数：11
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