SC-2001, a SHP-1 enhancer, induces apoptosis in hepatocellular carcinoma through SHP-1 dependent STAT3 inactivation

被引:0
|
作者
Chen, Kuen-Feng [1 ]
Su, Jung-Chen [2 ]
Chen, Wei-Lin [2 ]
Liu, Chun-Yu [3 ]
Cheng, Ann-Lii [4 ]
Chen, Pel-Jer [1 ]
Shiau, Chung-Wai [2 ]
机构
[1] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan
[2] Natl Yang Ming Univ, Inst Biopharmaceut Sci, Taipei 112, Taiwan
[3] Taipei Vet Gen Hosp, Dept Internal Med, Div Hematol & Oncol, Taipei, Taiwan
[4] Natl Taiwan Univ Hosp, Dept Oncol, Taipei, Taiwan
关键词
D O I
10.1158/1538-7445.AM2011-4516
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4516
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Dovitinib Induces Apoptosis and Overcomes Sorafenib Resistance in Hepatocellular Carcinoma through SHP-1-Mediated Inhibition of STAT3
    Tai, Wei-Tien
    Cheng, Ann-Lii
    Shiau, Chung-Wai
    Liu, Chun-Yu
    Ko, Ching-Huai
    Lin, Mai-Wei
    Chen, Pei-Jer
    Chen, Kuen-Feng
    MOLECULAR CANCER THERAPEUTICS, 2012, 11 (02) : 452 - 463
  • [42] Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1
    Song, Shiyu
    Su, Zhonglan
    Xu, Hui
    Niu, Mengyuan
    Chen, Xiufang
    Min, Haiyan
    Zhang, Bin
    Sun, Guibo
    Xie, Sijing
    Wang, Hongwei
    Gao, Qian
    CELL DEATH & DISEASE, 2017, 8 : e2612 - e2612
  • [43] SHP-1/STAT3 Interaction Is Related to Luteolin-Induced Myocardial Ischemia Protection
    Liu, Donghai
    Luo, Hong
    Qiao, Chenhui
    INFLAMMATION, 2022, 45 (01) : 88 - 99
  • [44] SHP-1/STAT3 Interaction Is Related to Luteolin-Induced Myocardial Ischemia Protection
    Donghai Liu
    Hong Luo
    Chenhui Qiao
    Inflammation, 2022, 45 : 88 - 99
  • [45] SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma
    Fan, L-C
    Shiau, C-W
    Tai, W-T
    Hung, M-H
    Chu, P-Y
    Hsieh, F-S
    Lin, H.
    Yu, H-C
    Chen, K-F
    ONCOGENE, 2015, 34 (41) : 5252 - 5263
  • [46] Design and synthesis of sorafenib analogues as SHP-1 activators for hepatocellular carcinoma cells
    Huang, Jui-Wen
    Chen, Kuen-Feng
    Tai, Wei-Tien
    Chen, Wei-Lin
    Chen, Pei-Jer
    Cheng, Ann-Lii
    Shiau, Chung-Wai
    CANCER RESEARCH, 2011, 71
  • [47] SHP-1 is a negative regulator of epithelial-mesenchymal transition in hepatocellular carcinoma
    Fan, Li-Ching
    Shiau, Chung-Wai
    Tai, Wei-Tien
    Hung, Man-Hsin
    Chu, Pei-Yi
    Lin, Hang
    Yu, Hui-Chuan
    Chen, Kuen-Feng
    CANCER RESEARCH, 2015, 75 (22)
  • [48] Correction: Luteolin selectively kills STAT3 highly activated gastric cancer cells through enhancing the binding of STAT3 to SHP-1
    Shiyu Song
    Zhonglan Su
    Hui Xu
    Mengyuan Niu
    Xiufang Chen
    Haiyan Min
    Bin Zhang
    Guibo Sun
    Sijing Xie
    Hongwei Wang
    Qian Gao
    Cell Death & Disease, 9
  • [49] Pantoprazole inhibits STAT3 signaling and EMT via induction of SHP-1 in gastric cancer cells
    Koh, Jin Sung
    Joo, Moon Kyung
    Yoo, Hyo Soon
    Park, Jong-Jae
    Yoon, Hyung Seok
    Shin, Yoon Ji
    Song, Kyoung Hwan
    Eom, Moon Yong
    Lee, Beom Jae
    Chun, Hoon Jai
    Lee, Sang Woo
    Bak, Young-Tae
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2017, 32 : 67 - 67
  • [50] A combination of sorafenib and SC-43 is a synergistic SHP-1 agonist duo to advance hepatocellular carcinoma therapy
    Chao, Tzu-I
    Tai, Wei-Tien
    Hung, Man-Hsin
    Tsai, Ming-Hsien
    Chen, Min-Hsuan
    Chang, Mao-Ju
    Shiau, Chung-Wai
    Chen, Kuen-Feng
    CANCER LETTERS, 2016, 371 (02) : 205 - 213